TMEFF2

Tomoregulin-2 is a protein that in humans is encoded by the TMEFF2 gene.[5][6]

TMEFF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FMW
Identifiers
Aliases	TMEFF2, CT120.2, HPP1, TENB2, TPEF, TR, TR-2, transmembrane protein with EGF like and two follistatin like domains 2
External IDs	OMIM: 605734 MGI: 1861735 HomoloGene: 9417 GeneCards: TMEFF2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.3 Start 191,949,043 bp[1] End 192,194,933 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1 Start 50,900,647 bp[2] End 51,187,270 bp[2]
Gene ontology Molecular function • molecular function Cellular component • integral component of membrane • extracellular region • membrane • cell membrane Biological process • negative regulation of integrin biosynthetic process • negative regulation of cell migration • negative regulation of stress fiber assembly • wound healing, spreading of cells • animal organ morphogenesis • histogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23671	56363
Ensembl	ENSG00000144339	ENSMUSG00000026109
UniProt	Q9UIK5	Q9QYM9
RefSeq (mRNA)	NM_001305134 NM_001305145 NM_016192	NM_019790
RefSeq (protein)	NP_001292063 NP_001292074 NP_057276	NP_062764
Location (UCSC)	Chr 2: 191.95 – 192.19 Mb	Chr 1: 50.9 – 51.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000144339 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Horie M, Mitsumoto Y, Kyushiki H, Kanemoto N, Watanabe A, Taniguchi Y, Nishino N, Okamoto T, Kondo M, Mori T, Noguchi K, Nakamura Y, Takahashi EI, Tanigami A (July 2000). "Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons". Genomics. 67 (2): 146–52. doi:10.1006/geno.2000.6228. PMID 10903839.
6. "Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2".

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Uchida T, Wada K, Akamatsu T, Yonezawa M, Noguchi H, Mizoguchi A, Kasuga M, Sakamoto C (December 1999). "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells". Biochemical and Biophysical Research Communications. 266 (2): 593–602. doi:10.1006/bbrc.1999.1873. PMID 10600548.
• Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA (September 2000). "The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells". Cancer Research. 60 (17): 4907–12. PMID 10987305.
• Young J, Biden KG, Simms LA, Huggard P, Karamatic R, Eyre HJ, Sutherland GR, Herath N, Barker M, Anderson GJ, Fitzpatrick DR, Ramm GA, Jass JR, Leggett BA (January 2001). "HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers". Proceedings of the National Academy of Sciences of the United States of America. 98 (1): 265–70. doi:10.1073/pnas.011415298. PMC 14579. PMID 11120884.
• Glynne-Jones E, Harper ME, Seery LT, James R, Anglin I, Morgan HE, Taylor KM, Gee JM, Nicholson RI (October 2001). "TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence". International Journal of Cancer. 94 (2): 178–84. doi:10.1002/ijc.1450. PMID 11668495.
• Shibata DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ (October 2002). "Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas". Cancer Research. 62 (20): 5637–40. PMID 12384516.
• Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru FM, Kimos MC, Hytiroglou P, Young J, Leggett B, Gazdar AF, Toyooka S, Abraham JM, Meltzer SJ (December 2002). "Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma". Cancer Research. 62 (23): 6820–2. PMID 12460892.
• Gery S, Koeffler HP (May 2003). "Repression of the TMEFF2 promoter by c-Myc". Journal of Molecular Biology. 328 (5): 977–83. doi:10.1016/S0022-2836(03)00404-2. PMID 12729735.
• Sabbioni S, Miotto E, Veronese A, Sattin E, Gramantieri L, Bolondi L, Calin GA, Gafà R, Lanza G, Carli G, Ferrazzi E, Feo C, Liboni A, Gullini S, Negrini M (2004). "Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood". Molecular Diagnosis. 7 (3–4): 201–7. doi:10.2165/00066982-200307030-00010. PMID 15068392.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS, Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ (June 2005). "Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk". Oncogene. 24 (25): 4138–48. doi:10.1038/sj.onc.1208598. PMID 15824739.
• Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Frenkel EP, Minna JD, Fujisawa T, Gazdar AF (October 2005). "DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers". British Journal of Cancer. 93 (9): 1029–37. doi:10.1038/sj.bjc.6602837. PMC 2361683. PMID 16234815.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.