Thrombospondin-2

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.[5][6]

THBS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YO8, 2RHP
Identifiers
Aliases	THBS2, TSP2, thrombospondin 2
External IDs	OMIM: 188061 MGI: 98738 HomoloGene: 2438 GeneCards: THBS2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 169,215,780 bp[1] End 169,254,044 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A2|17 8.95 cM Start 14,665,500 bp[2] End 14,694,235 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • GO:0001948 protein binding • heparin binding • extracellular matrix structural constituent Cellular component • proteinaceous extracellular matrix • extracellular matrix • platelet alpha granule • basement membrane • extracellular region • extracellular • collagen-containing extracellular matrix Biological process • positive regulation of synapse assembly • negative regulation of angiogenesis • cell adhesion • extracellular matrix organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7058	21826
Ensembl	ENSG00000186340	ENSMUSG00000023885
UniProt	P35442	Q03350
RefSeq (mRNA)	NM_003247	NM_011581
RefSeq (protein)	NP_003238 NP_001368868 NP_001368869 NP_001368870 NP_001368871	NP_035711
Location (UCSC)	Chr 6: 169.22 – 169.25 Mb	Chr 17: 14.67 – 14.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.[6]

Interactions

THBS2 has been shown to interact with MMP2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000186340 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023885 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics. 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130.
6. "Entrez Gene: THBS2 thrombospondin 2".
7. Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.

Further reading

• Bornstein P, Kyriakides TR, Yang Z, Armstrong LC, Birk DE (Dec 2000). "Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis". The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 61–6. doi:10.1046/j.1087-0024.2000.00005.x. PMID 11147677.
• O'Rourke KM, Laherty CD, Dixit VM (Dec 1992). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". The Journal of Biological Chemistry. 267 (35): 24921–4. PMID 1459996.
• LaBell TL, Milewicz DJ, Disteche CM, Byers PH (Mar 1992). "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans". Genomics. 12 (3): 421–9. doi:10.1016/0888-7543(92)90430-Z. PMID 1559694.
• LaBell TL, Byers PH (Jul 1993). "Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region". Genomics. 17 (1): 225–9. doi:10.1006/geno.1993.1308. PMID 8406456.
• Adolph KW, Liska DJ, Bornstein P (Jul 1997). "Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2)". Gene. 193 (1): 5–11. doi:10.1016/S0378-1119(97)00070-X. PMID 9249061.
• Kyriakides TR, Zhu YH, Smith LT, Bain SD, Yang Z, Lin MT, Danielson KG, Iozzo RV, LaMarca M, McKinney CE, Ginns EI, Bornstein P (Jan 1998). "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis". The Journal of Cell Biology. 140 (2): 419–30. doi:10.1083/jcb.140.2.419. PMC 2132586. PMID 9442117.
• Adolph KW (May 1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochemical and Biophysical Research Communications. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
• Carron JA, Bowler WB, Wagstaff SC, Gallagher JA (Sep 1999). "Expression of members of the thrombospondin family by human skeletal tissues and cultured cells". Biochemical and Biophysical Research Communications. 263 (2): 389–91. doi:10.1006/bbrc.1999.1380. PMID 10491303.
• Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.
• Hawighorst T, Velasco P, Streit M, Hong YK, Kyriakides TR, Brown LF, Bornstein P, Detmar M (Jun 2001). "Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism". The EMBO Journal. 20 (11): 2631–40. doi:10.1093/emboj/20.11.2631. PMC 125494. PMID 11387198.
• Misenheimer TM, Hahr AJ, Harms AC, Annis DS, Mosher DF (Dec 2001). "Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2". The Journal of Biological Chemistry. 276 (49): 45882–7. doi:10.1074/jbc.M104218200. PMID 11590138.
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S (Jun 2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". The International Journal of Biochemistry & Cell Biology. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
• Li Z, Calzada MJ, Sipes JM, Cashel JA, Krutzsch HC, Annis DS, Mosher DF, Roberts DD (Apr 2002). "Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior". The Journal of Cell Biology. 157 (3): 509–19. doi:10.1083/jcb.200109098. PMC 2173289. PMID 11980922.
• Armstrong LC, Björkblom B, Hankenson KD, Siadak AW, Stiles CE, Bornstein P (Jun 2002). "Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism". Molecular Biology of the Cell. 13 (6): 1893–905. doi:10.1091/mbc.E01-09-0066. PMC 117612. PMID 12058057.
• Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Miyamori I, Uchida K (Jul 2002). "Thrombospondin expression in aldosterone-producing adenomas". Hypertension Research. 25 (4): 523–7. doi:10.1291/hypres.25.523. PMID 12358136.
• Boekholdt SM, Trip MD, Peters RJ, Engelen M, Boer JM, Feskens EJ, Zwinderman AH, Kastelein JJ, Reitsma PH (Dec 2002). "Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (12): e24–7. doi:10.1161/01.ATV.0000046235.22451.66. PMID 12482844.
• Kyriakides TR, Rojnuckarin P, Reidy MA, Hankenson KD, Papayannopoulou T, Kaushansky K, Bornstein P (May 2003). "Megakaryocytes require thrombospondin-2 for normal platelet formation and function". Blood. 101 (10): 3915–23. doi:10.1182/blood.V101.10.3915. PMID 12732502.
• Kishi M, Nakamura M, Nishimine M, Ishida E, Shimada K, Kirita T, Konishi N (Jun 2003). "Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas". Cancer Science. 94 (6): 530–5. doi:10.1111/j.1349-7006.2003.tb01478.x. PMID 12824879.