TESK1

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.[5][6]

TESK1
Identifiers
AliasesTESK1, testis-specific kinase 1, testis associated actin remodelling kinase 1
External IDsOMIM: 601782 MGI: 1201675 HomoloGene: 4577 GeneCards: TESK1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9p13.3Start35,605,262 bp[1]
End35,610,041 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7016

21754

Ensembl

ENSG00000107140

ENSMUSG00000028458

UniProt

Q15569

O70146

RefSeq (mRNA)

NM_006285
NM_001318230

NM_011571

RefSeq (protein)

NP_001305159
NP_006276

NP_035701

Location (UCSC)Chr 9: 35.61 – 35.61 MbChr 4: 43.44 – 43.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.[6]

Interactions

TESK1 has been shown to interact with YWHAB[7] and SPRY4.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000107140 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028458 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K (December 29, 1995). "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J. Biol. Chem. 270 (52): 31331–7. doi:10.1074/jbc.270.52.31331. PMID 8537404.
  6. "Entrez Gene: TESK1 testis-specific kinase 1".
  7. Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
  8. Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Further reading


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