TAX1BP1

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.[5]

TAX1BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M7Q, 4BMJ, 4NLH, 5AAS, 4Z4M, 4Z4K
Identifiers
Aliases	TAX1BP1, CALCOCO3, T6BP, TXBP151, Tax1 binding protein 1
External IDs	OMIM: 605326 MGI: 1289308 HomoloGene: 4395 GeneCards: TAX1BP1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,739,331 bp[1] End 27,844,564 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.7 cM Start 52,713,729 bp[2] End 52,766,780 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinase binding • GO:0001948 protein binding • metal ion binding Cellular component • cytosol • extracellular exosome Biological process • regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of type I interferon production • negative regulation of apoptotic process • negative regulation of NF-kappaB transcription factor activity • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8887	52440
Ensembl	ENSG00000106052	ENSMUSG00000004535
UniProt	Q86VP1	Q3UKC1
RefSeq (mRNA)	NM_001079864 NM_001206901 NM_001206902 NM_006024 NM_001362794 NM_001362795	NM_025816 NM_001355595 NM_001355596
RefSeq (protein)	NP_001073333 NP_001193830 NP_001193831 NP_006015 NP_001349723 NP_001349724	NP_080092 NP_001342524 NP_001342525
Location (UCSC)	Chr 7: 27.74 – 27.84 Mb	Chr 6: 52.71 – 52.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TAX1BP1 has been shown to interact with TNFAIP3[6] and TRAF6.[7] TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation.

References

1. GRCh38: Ensembl release 89: ENSG00000106052 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004535 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1".
6. De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. PMID 10435631.
7. Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi:10.1073/pnas.170279097. PMC 16905. PMID 10920205.

Further reading

• "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
• De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. PMID 10435631.
• Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi:10.1073/pnas.170279097. PMC 16905. PMID 10920205.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (June 2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Letters. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905.
• Dodon MD, Hamaia S, Martin J, Gazzolo L (May 2002). "Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element". The Journal of Biological Chemistry. 277 (21): 18744–52. doi:10.1074/jbc.M109087200. PMID 11893730.
• Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F (January 2004). "Protein profile of tax-associated complexes". The Journal of Biological Chemistry. 279 (1): 495–508. doi:10.1074/jbc.M310069200. PMID 14530271.
• Nagaraja GM, Kandpal RP (January 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F (August 2007). "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion". Journal of Cell Science. 120 (Pt 15): 2574–85. doi:10.1242/jcs.007005. PMC 2621013. PMID 17635994.