TAOK3

Serine/threonine-protein kinase TAO3 is an enzyme that in humans is encoded by the TAOK3 gene.[5][6][7]

TAOK3
Identifiers
Aliases	TAOK3, DPK, JIK, MAP3K18, TAO kinase 3, hKFC-A
External IDs	OMIM: 616711 MGI: 3041177 HomoloGene: 83279 GeneCards: TAOK3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 118,149,801 bp[1] End 118,372,907 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 117,120,129 bp[2] End 117,275,219 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein kinase inhibitor activity • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • MAP kinase kinase kinase activity Cellular component • cytoplasm • membrane • cell membrane • cell nucleus Biological process • phosphorylation • positive regulation of JUN kinase activity • positive regulation of JNK cascade • MAPK cascade • cellular response to DNA damage stimulus • negative regulation of JNK cascade • protein phosphorylation • autophosphorylation • mitotic G2 DNA damage checkpoint • DNA repair • positive regulation of stress-activated MAPK cascade • negative regulation of protein kinase activity • activation of MAPKK activity • nervous system development • regulation of apoptotic process • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51347	330177
Ensembl	ENSG00000135090	ENSMUSG00000061288
UniProt	Q9H2K8	Q8BYC6
RefSeq (mRNA)	NM_001346487 NM_001346488 NM_001346489 NM_001346490 NM_001346491 NM_001346492 NM_001346493 NM_001346494 NM_001346495 NM_001346496 NM_001346497 NM_016281	NM_001081308 NM_001199685 NM_183306
RefSeq (protein)	NP_001333416 NP_001333417 NP_001333418 NP_001333419 NP_001333420 NP_001333421 NP_001333422 NP_001333423 NP_001333424 NP_001333425 NP_001333426 NP_057365	NP_001074777 NP_001186614 NP_899129
Location (UCSC)	Chr 12: 118.15 – 118.37 Mb	Chr 5: 117.12 – 117.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000135090 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT (Dec 1999). "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor". J Biol Chem. 274 (47): 33287–95. doi:10.1074/jbc.274.47.33287. PMID 10559204.
6. Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X (Sep 2000). "Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways". Biochem Biophys Res Commun. 274 (3): 872–9. doi:10.1006/bbrc.2000.3244. PMID 10924369.
7. "Entrez Gene: TAOK3 TAO kinase 3".

Further reading

• Yoneda T, Imaizumi K, Oono K, et al. (2001). "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress". J. Biol. Chem. 276 (17): 13935–40. doi:10.1074/jbc.M010677200. PMID 11278723.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.