TAGLN2

Transgelin-2 is a protein that in humans is encoded by the TAGLN2 gene.[5][6]

TAGLN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYM
Identifiers
Aliases	TAGLN2, HA1756, transgelin 2
External IDs	OMIM: 604634 MGI: 1312985 HomoloGene: 20789 GeneCards: TAGLN2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 159,918,107 bp[1] End 159,925,732 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.89 cM Start 172,500,047 bp[2] End 172,507,380 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • cadherin binding Cellular component • vesicle • extracellular exosome • extracellular region • cytosol Biological process • epithelial cell differentiation • platelet degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8407	21346
Ensembl	ENSG00000158710	ENSMUSG00000026547
UniProt	P37802	Q9WVA4
RefSeq (mRNA)	NM_003564 NM_001277223 NM_001277224	NM_178598
RefSeq (protein)	NP_001264152 NP_001264153 NP_003555	NP_848713
Location (UCSC)	Chr 1: 159.92 – 159.93 Mb	Chr 1: 172.5 – 172.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a homolog of the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The function of this protein has not yet been determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000158710 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026547 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stanier P, Abu-Hayyeh S, Murdoch JN, Eddleston J, Copp AJ (Sep 1998). "Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship". Genomics. 51 (1): 144–7. doi:10.1006/geno.1998.5381. PMID 9693045.
6. "Entrez Gene: TAGLN2 transgelin 2".

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.