TAF9B

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.[5][6]

TAF9B
Identifiers
Aliases	TAF9B, DN-7, DN7, TAF9L, TAFII31L, TFIID-31, TATA-box binding protein associated factor 9b
External IDs	OMIM: 300754 MGI: 3039562 HomoloGene: 47969 GeneCards: TAF9B
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,129,748 bp[1] End 78,139,650 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 106,206,883 bp[2] End 106,221,158 bp[2]
Gene ontology Molecular function • protein heterodimerization activity • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • histone acetyltransferase activity • transcription factor binding • thiol-dependent ubiquitinyl hydrolase activity • GO:0000983 RNA polymerase II general transcription initiation factor activity Cellular component • cell nucleus • transcription factor TFTC complex • nucleoplasm • transcription factor TFIID complex • SAGA complex Biological process • protein stabilization • regulation of transcription, DNA-templated • positive regulation of cell growth • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • DNA-templated transcription, initiation • transcription from RNA polymerase II promoter • negative regulation of apoptotic process • regulation of signal transduction by p53 class mediator • protein deubiquitination • histone H3 acetylation • positive regulation of transcription from RNA polymerase II promoter • RNA polymerase II transcriptional preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51616	407786
Ensembl	ENSG00000187325	ENSMUSG00000047242
UniProt	Q9HBM6	Q6NZA9
RefSeq (mRNA)	NM_015975	NM_001001176 NM_001167988
RefSeq (protein)	NP_057059	NP_001001176 NP_001161460
Location (UCSC)	Chr X: 78.13 – 78.14 Mb	Chr X: 106.21 – 106.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000187325 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047242 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Frontini M, Soutoglou E, Argentini M, Bole-Feysot C, Jost B, Scheer E, Tora L (May 2005). "TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9". Mol Cell Biol. 25 (11): 4638–49. doi:10.1128/MCB.25.11.4638-4649.2005. PMC 1140618. PMID 15899866.
6. "Entrez Gene: TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa".

Further reading

• Albright SR, Tjian R (2000). "TAFs revisited: more data reveal new twists and confirm old ideas". Gene. 242 (1–2): 1–13. doi:10.1016/S0378-1119(99)00495-3. PMID 10721692.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen Z, Manley JL (2003). "In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L". J. Biol. Chem. 278 (37): 35172–83. doi:10.1074/jbc.M304241200. PMID 12837753.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lu H, Levine AJ (1995). "Human TAFII31 protein is a transcriptional coactivator of the p53 protein". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 5154–8. doi:10.1073/pnas.92.11.5154. PMC 41867. PMID 7761466.