TAF9B

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.[5][6]

TAF9B
Identifiers
AliasesTAF9B, DN-7, DN7, TAF9L, TAFII31L, TFIID-31, TATA-box binding protein associated factor 9b
External IDsOMIM: 300754 MGI: 3039562 HomoloGene: 47969 GeneCards: TAF9B
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq21.1Start78,129,748 bp[1]
End78,139,650 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51616

407786

Ensembl

ENSG00000187325

ENSMUSG00000047242

UniProt

Q9HBM6

Q6NZA9

RefSeq (mRNA)

NM_015975

NM_001001176
NM_001167988

RefSeq (protein)

NP_057059

NP_001001176
NP_001161460

Location (UCSC)Chr X: 78.13 – 78.14 MbChr X: 106.21 – 106.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000187325 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047242 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Frontini M, Soutoglou E, Argentini M, Bole-Feysot C, Jost B, Scheer E, Tora L (May 2005). "TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9". Mol Cell Biol. 25 (11): 4638–49. doi:10.1128/MCB.25.11.4638-4649.2005. PMC 1140618. PMID 15899866.
  6. "Entrez Gene: TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa".

Further reading

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