T-cell vaccine

A T-cell vaccine is a vaccine designed to induce protective T-cells.[1]

For vaccination with T cells, see T-cell vaccination.

T-cell vaccines are designed to induce cellular immunity. They are also referred to as cell-mediated immune (CMI) vaccines.[2]

It is thought that they can be more effective than conventional B-cell vaccines for protection from microbes that hide inside host cells, and viruses (such as HIV or influenza) that mutate rapidly.

T-cell vaccines underwent clinical trials for HIV/AIDS.[3]

As of July 2012 none have been approved.[4]

References
  1. Robinson, Harriet L.; Amara, Rama Rao (2005). "T cell vaccines for microbial infections". Nature Medicine. 11 (4s): S25–S32. doi:10.1038/nm1212. PMID 15812486.
  2. Buchbinder, SP; Mehrotra, DV; Duerr, A; Fitzgerald, DW; Mogg, R; Li, D; Gilbert, PB; Lama, JR; Marmor, M; Del Rio, C; McElrath, MJ; Casimiro, DR; Gottesdiener, KM; Chodakewitz, JA; Corey, L; Robertson, MN (2008). "Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial". Lancet. 372 (9653): 1881–93. doi:10.1016/S0140-6736(08)61591-3. PMC 2721012. PMID 19012954.
  3. "T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces". 2009. Cite journal requires |journal= (help)
  4. "T-cell Vaccines Could Treat Elusive Diseases".


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