Suresh H. Moolgavkar
Suresh H. Moolgavkar M.D., Ph.D. (born 3 January 1943 in Bombay, India) is a mathematician and epidemiologist at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. Among his many scientific contributions is the development of the two-stage clonal expansion (TSCE) model of carcinogenesis, also known as the Moolgavkar-Venzon-Knudson (MVK) model, a stochastic cell-level description of carcinogenesis based on Alfred G. Knudson’s two-hit hypothesis.[1] In its original development the TSCE model[2] represents tumor initiation as the first hit, followed by cell proliferation (clonal expansion) and malignant transformation as the second hit. It has been interpreted as describing the initiation-promotion-progression sequence observed in chemical carcinogenesis and has been applied widely for the analysis of both experimental and epidemiological data for purposes of quantitative risk assessment.
Suresh H. Moolgavkar M.D., Ph.D. | |
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| Born | 3 January 1943 Bombay, India |
| Alma mater | Johns Hopkins University |
| Known for | Two-stage Clonal Expansion (TSCE) Model of Carcinogenesis |
| Scientific career | |
| Fields | Epidemiology, Mathematics |
| Institutions | University of Washington, Fred Hutchinson Cancer Research Center |
References
- Knudson, Alfred G Jr. (1971). "Mutation and cancer: Statistical study of retinoblastoma". Proc Natl Acad Sci USA. 68 (4): 820–823. doi:10.1073/pnas.68.4.820. PMC 389051. PMID 5279523.
- Moolgavkar, Suresh H.; Knudson AG (1981). "Mutation and cancer: A model for human carcinogenesis". JNCI. 66 (6): 1037–1052. doi:10.1093/jnci/66.6.1037. PMID 6941039.