Streptomyces tsukubaensis
Streptomyces tsukubaensis is a species of actinobacteria. It produces the immunosuppressive drug tacrolimus.[1][2] Tacrolimus was first isolated from S. tsukubaensis in 1984.[3]
| Streptomyces tsukubaensis | |
|---|---|
| Scientific classification | |
| Kingdom: | |
| Phylum: | |
| Class: | Actinobacteria |
| Order: | |
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| Species: | S. tsukubaensis |
| Binomial name | |
| Streptomyces tsukubaensis | |
References
- Pritchard D (2005). "Sourcing a chemical succession for cyclosporin from parasites and human pathogens". Drug Discov Today. 10 (10): 688–91. doi:10.1016/S1359-6446(05)03395-7. PMID 15896681. Supports source organism, but not team information
- Blažič, Marko; Kosec, Gregor; Baebler, Špela; Gruden, Kristina; Petković, Hrvoje (2015). "Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis". Microbial Cell Factories. 14: 164. doi:10.1186/s12934-015-0352-z. PMC 4606968. PMID 26466669.
- Pirsch, JD; Miller, J; Deierhoi, MH; Vincenti, F; Filo, RS (15 April 1997). "A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group". Transplantation. 63 (7): 977–83. doi:10.1097/00007890-199704150-00013. PMID 9112351. Retrieved 28 August 2018.
Further reading
Du, W; Huang, D; Xia, M; Wen, J; Huang, M (July 2014). "Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies". Journal of Industrial Microbiology & Biotechnology. 41 (7): 1131–43. doi:10.1007/s10295-014-1450-3. PMID 24788378.
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