SroB RNA

The sroB RNA (also known as MicM, rybC, or ChiX) is a non-coding RNA gene of 90 nucleotides in length. sroB is found in several Enterobacterial species but its function is unknown.[1][2] SroB is found in the intergenic region on the opposite strand to the ybaK and ybaP genes.[1] SroB is expressed in stationary phase.[1] Experiments have shown that SroB is a Hfq binding sRNA.[2][3]

sroB RNA
Predicted secondary structure and sequence conservation of sroB
Identifiers
SymbolsroB
RfamRF00368
Other data
RNA typeGene; sRNA
Domain(s)Bacteria
SO0000655
PDB structuresPDBe

Further evidence has shown that SroB negatively regulates the outer membrane protein YbfM by sequestering the ribosome binding site of ybfM mRNA by an antisense interaction.[4] SroB also regulates the DpiA/DpiB two-component system.[5] Furthermore, SroB itself appears to be the target of a non-coding transcript from the chbBC intergenic region.[6][7][8]

References
  1. Vogel J, Bartels V, Tang TH, et al. (2003). "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Res. 31 (22): 6435–6443. doi:10.1093/nar/gkg867. PMC 275561. PMID 14602901.
  2. Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S (November 2003). "Global analysis of small RNA and mRNA targets of Hfq". Mol. Microbiol. 50 (4): 1111–1124. doi:10.1046/j.1365-2958.2003.03734.x. PMID 14622403. Archived from the original on 2013-01-05.
  3. Sittka A, Lucchini S, Papenfort K, et al. (2008). Burkholder WF (ed.). "Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq". PLoS Genet. 4 (8): e1000163. doi:10.1371/journal.pgen.1000163. PMC 2515195. PMID 18725932.
  4. Rasmussen AA, Johansen J, Nielsen JS, Overgaard M, Kallipolitis B, Valentin-Hansen P (April 2009). "A conserved small RNA promotes silencing of the outer membrane protein YbfM". Mol. Microbiol. 72 (3): 566–577. doi:10.1111/j.1365-2958.2009.06688.x. PMID 19400782. Archived from the original on 2013-01-05.
  5. Mandin, P.; Gottesman, S. (2009). "A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system". Molecular Microbiology. 72 (3): 551–565. doi:10.1111/j.1365-2958.2009.06665.x. PMC 2714224. PMID 19426207.
  6. Overgaard M, Johansen J, Møller-Jensen J, Valentin-Hansen P (2009). "Switching off small RNA regulation with trap-mRNA". Mol Microbiol. 73 (5): 790–800. doi:10.1111/j.1365-2958.2009.06807.x. PMID 19682266.
  7. Vogel J (July 2009). "An RNA trap helps bacteria get the most out of chitosugars". Mol. Microbiol. 73 (5): 737–741. doi:10.1111/j.1365-2958.2009.06806.x. PMID 19659640. Archived from the original on 2013-01-05.
  8. Figueroa-Bossi N, Valentini M, Malleret L, Fiorini F, Bossi L (2009). "Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target". Genes Dev. 23 (17): 2004–2015. doi:10.1101/gad.541609. PMC 2751969. PMID 19638370.

Further reading
  • Plumbridge J, Bossi L, Oberto J, Wade JT, Figueroa-Bossi N (March 5, 2014). "Interplay of transcriptional and small RNA-dependent control mechanisms regulates chitosugar uptake in Escherichia coli and Salmonella". Molecular Microbiology. 92 (4): 648–658. doi:10.1111/mmi.12573. PMID 24593230.
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