Sprague effect

The Sprague effect is the phenomenon of the amelioration of homonymous hemianopia, caused by damage to visual cortex, by means of destruction of the contralesional superior colliculus.[1][2] The effect is named for its discoverer, James Sprague, who observed this phenomenon in 1966 using the feline model.[3] Several explanations have been proposed for this phenomenon, including mutual inhibition between the two brain hemispheres.[4] For similar reasons of inhibiting an inhibitory structure, the lesioning of the substantia nigra, for instance by means of ibotenic acid, can also produce the same hemianopic amelioration.[5]

References
  1. Weddell, Rodger A. (August 2004). "Subcortical modulation of spatial attention including evidence that the Sprague effect extends to man". Brain and Cognition. 55 (3): 497–506. doi:10.1016/j.bandc.2004.02.075. PMID 15223196.
  2. Lomber, Stephen G.; Malhotra, Shveta; Sprague, James M. (2007-02-01). "Restoration of Acoustic Orienting Into a Cortically Deaf Hemifield by Reversible Deactivation of the Contralesional Superior Colliculus: The Acoustic "Sprague Effect"". Journal of Neurophysiology. United States: Journal of Applied Physiology. 97 (2): 979–993. doi:10.1152/jn.00767.2006. PMID 17151228.
  3. Sprague, James M. (1966-09-23). "Interaction of Cortex and Superior Colliculus in Mediation of Visually Guided Behavior in the Cat". Science. 153 (3743): 1544–1547. doi:10.1126/science.153.3743.1544. PMID 5917786.
  4. Hilgetag, Claus C. (2000-06-01). "Spatial neglect and paradoxical lesion effects in the cat — A model based on midbrain connectivity". Neurocomputing. ScienceDirect. 32-33: 793–799. doi:10.1016/S0925-2312(00)00246-0.
  5. Wallace, Steven F.; Rosenquist, Alan C.; Sprague, James M. (1990). "Ibotenic acid lesions of the lateral substantia nigra restore visual orientation behavior in the hemianopic cat". The Journal of Comparative Neurology. Wiley-Blackwell. 296 (2): 222–252. doi:10.1002/cne.902960204.
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