SprA1/SprA1as toxin/antitoxin system

The SprA1/SPrA1as toxin/antitoxin system identified in Staphylococcus aureus, belongs to the Type I system encoding toxin protein: SprA1 and antitoxin RNA: SprA1as. The SprA1as postranscriptionally regulates SprA1 encoding small membrane damaging protein PepA1.[1][2]

References
  1. Sayed N, Jousselin A, Felden B (December 2011). "A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide". Nature Structural & Molecular Biology. 19 (1): 105–12. doi:10.1038/nsmb.2193. PMID 22198463.
  2. Sayed N, Nonin-Lecomte S, Réty S, Felden B (December 2012). "Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module". The Journal of Biological Chemistry. 287 (52): 43454–63. doi:10.1074/jbc.M112.402693. PMC 3527932. PMID 23129767.


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