Spitz (protein)

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Structures	Swiss-model
Domains	InterPro

Spitz
Identifiers
Organism	?
Symbol	SPI
Entrez	35253
PDB	3LTF
UniProt	Q01083
Search for
Structures	Swiss-model
Domains	InterPro

Spitz is a protein in fruit flies which is the major activator of Epidermal Growth Factor Receptor (EGFR).[1]

Unknown parameter RefSeq

Function

Spitz is produced as a transmembrane protein in the endoplasmic reticulum. There it associates with a cargo receptor called Star and is trafficked to the Golgi. In the Golgi, Spitz is cleaved by a protease called Rhomboid, which releases Spitz to be trafficked to the cell membrane and released out of the cell.[1] From here it can bind EGFR on the surface of other cells, activating the receptor. Alternatively, Spitz can be bound and inactivated by Argos, inhibiting EGFR activation.[2]

Structure

Spitz is structurally similar to TGF-α.[1]

References

Shilo BZ (2003). "Signaling by the Drosophila epidermal growth factor receptor pathway during development". Experimental Cell Research. 284 (1): 140–9. doi:10.1016/S0014-4827(02)00094-0. PMID 12648473.
Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA (2004). "Argos inhibits epidermal growth factor receptor signalling by ligand sequestration". Nature. 430 (7003): 1040–4. doi:10.1038/nature02840. PMID 15329724.

External links

Spitz on FlyBase, the Drosophila gene database.

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[Shilo-1] Shilo BZ (2003). "Signaling by the Drosophila epidermal growth factor receptor pathway during development". Experimental Cell Research. 284 (1): 140–9. doi:10.1016/S0014-4827(02)00094-0. PMID 12648473.

[Klein-2] Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA (2004). "Argos inhibits epidermal growth factor receptor signalling by ligand sequestration". Nature. 430 (7003): 1040–4. doi:10.1038/nature02840. PMID 15329724.