Spermatogenesis associated 13

Spermatogenesis associated 13 is a protein that in humans is encoded by the SPATA13 gene. [5]

SPATA13
Identifiers
Aliases	SPATA13, ARHGEF29, ASEF2, spermatogenesis associated 13
External IDs	OMIM: 613324 MGI: 104838 HomoloGene: 19482 GeneCards: SPATA13
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.12 Start 23,979,805 bp[1] End 24,307,074 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 31.77 cM Start 60,634,001 bp[2] End 60,764,556 bp[2]
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • GO:0001948 protein binding • guanyl-nucleotide exchange factor activity • identical protein binding Cellular component • cytoplasm • filopodium • ruffle membrane • cell membrane • cell projection • membrane • lamellipodium • nucleoplasm • cytosol Biological process • filopodium assembly • regulation of Rho protein signal transduction • regulation of cell migration • cell migration • lamellipodium assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221178	219140
Ensembl	ENSG00000182957	ENSMUSG00000021990
UniProt	Q96N96	Q5DU57
RefSeq (mRNA)	NM_001166271 NM_001286792 NM_001286793 NM_001286794 NM_001286795 NM_153023	NM_001033272 NM_001310594
RefSeq (protein)	NP_001159743 NP_001273721 NP_001273722 NP_001273723 NP_001273724 NP_694568 NP_694568.1	NP_001028444 NP_001297523
Location (UCSC)	Chr 13: 23.98 – 24.31 Mb	Chr 14: 60.63 – 60.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000182957 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021990 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Spermatogenesis associated 13". Retrieved 2018-04-26.

Further reading

• Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, Akiyama T (December 2007). "Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42". Oncogene. 26 (55): 7620–267. doi:10.1038/sj.onc.1210574. PMID 17599059.
• Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T (March 2009). "Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration". Oncogene. 28 (10): 1357–65. doi:10.1038/onc.2008.478. PMID 19151759.
• Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, Hui R, Wang DW (January 2010). "Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke". Stroke. 41 (1): 177–80. doi:10.1161/STROKEAHA.109.567099. PMID 19910543.
• Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ (December 2009). "The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration". J. Cell Sci. 122 (Pt 24): 4535–46. doi:10.1242/jcs.053728. PMC 2787464. PMID 19934221.
• Jean L, Majumdar D, Shi M, Hinkle LE, Diggins NL, Ao M, Broussard JA, Evans JC, Choma DP, Webb DJ (December 2013). "Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen". J. Cell Sci. 126 (Pt 24): 5585–97. doi:10.1242/jcs.131060. PMC 3860307. PMID 24144700.