Sperm-associated antigen 6

Sperm-associated antigen 6 is a protein that in humans is encoded by the SPAG6 gene.[4][5]

SPAG6
Identifiers
Aliases	SPAG6, CT141, Repro-SA-1, pf16, sperm associated antigen 6, FAP194, CFAP194
External IDs	OMIM: 605730 MGI: 1354388 HomoloGene: 8252 GeneCards: SPAG6
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.2 Start 22,345,445 bp[1] End 22,454,224 bp[1]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9576	50525
Ensembl	ENSG00000077327	ENSMUSG00000022783
UniProt	O75602	Q9JLI7
RefSeq (mRNA)	NM_001253854 NM_001253855 NM_012443 NM_172242	NM_015773
RefSeq (protein)	NP_001240783 NP_001240784 NP_036575 NP_758442	NP_056588
Location (UCSC)	Chr 10: 22.35 – 22.45 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000077327 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Neilson LI, Schneider PA, Van Deerlin PG, Kiriakidou M, Driscoll DA, Pellegrini MC, Millinder S, Yamamoto KK, French CK, Strauss JF (September 1999). "cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus". Genomics. 60 (3): 272–80. doi:10.1006/geno.1999.5914. PMID 10493827.
5. "Entrez Gene: SPAG6 sperm associated antigen 6".

Further reading

• Diekman AB, Herr JC (January 1997). "Sperm antigens and their use in the development of an immunocontraceptive". American Journal of Reproductive Immunology. 37 (1): 111–7. doi:10.1111/j.1600-0897.1997.tb00199.x. PMID 9138444.
• Smith EF, Lefebvre PA (1997). "The role of central apparatus components in flagellar motility and microtubule assembly". Cell Motility and the Cytoskeleton. 38 (1): 1–8. doi:10.1002/(SICI)1097-0169(1997)38:1<1::AID-CM1>3.0.CO;2-C. PMID 9295136.
• Sapiro R, Tarantino LM, Velazquez F, Kiriakidou M, Hecht NB, Bucan M, Strauss JF (March 2000). "Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus". Biology of Reproduction. 62 (3): 511–8. doi:10.1095/biolreprod62.3.511. PMID 10684790.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Sapiro R, Kostetskii I, Olds-Clarke P, Gerton GL, Radice GL, Strauss III JF (September 2002). "Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6". Molecular and Cellular Biology. 22 (17): 6298–305. doi:10.1128/MCB.22.17.6298-6305.2002. PMC 134010. PMID 12167721.
• Zhang Z, Sapiro R, Kapfhamer D, Bucan M, Bray J, Chennathukuzhi V, McNamara P, Curtis A, Zhang M, Blanchette-Mackie EJ, Strauss JF (November 2002). "A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16". Molecular and Cellular Biology. 22 (22): 7993–8004. doi:10.1128/MCB.22.22.7993-8004.2002. PMC 134734. PMID 12391165.
• Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE (March 2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". The Journal of Biological Chemistry. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.