Sosuga pararubulavirus

Sosuga pararubulavirus
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Negarnaviricota
Class:	Monjiviricetes
Order:	Mononegavirales
Family:	Paramyxoviridae
Genus:	Pararubulavirus
Species:	Sosuga pararubulavirus
Synonyms[1]
	Sosuga rubulavirus;

Sosuga pararubulavirus is a species of Paramyxovirus which is transmissible to humans.[2] The Egyptian fruit bat is thought to be a natural reservoir species for the virus.[3]

History

In August 2012, following a six-week field trip to South Sudan and Uganda to collect bats and rodents, an American wildlife biologist became ill with symptoms including fever, malaise, headache, pain, stiffness in the neck, and a sore throat. Upon her return to the US, she was admitted to hospital, where she soon developed a maculopapular rash and oropharyngeal ulceration. Several suspect infections, including Ebola and Marburg, were ruled out through standard diagnostic testing. Genetic sequencing identified a novel virus. To determine the source, tissue samples collected during the three-week period prior to the illness were tested for this new Sosuga virus, and several Egyptian fruit bats were found to be positive. Analysis of historical samples of these bats from sites in Uganda found additional positive individuals, suggesting that this species may be a natural reservoir for Sosuga.

Treatment

Research has identified several compounds which inhibit replication of the Sosuga virus.[4]

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References

Balkema-Buschmann, Anne; et al. (6 June 2018). "Re-organization of the family Paramyxoviridae" (xls). International Committee on Taxonomy of Viruses. Retrieved 22 September 2019.
Albariño CG, Foltzer M, Towner JS, Rowe LA, Campbell S, Jaramillo CM, et al. (February 2014). "Novel paramyxovirus associated with severe acute febrile disease, South Sudan and Uganda, 2012". Emerging Infectious Diseases. 20 (2): 211–6. doi:10.3201/eid2002.131620. PMC 3901491. PMID 24447466.
Amman BR, Albariño CG, Bird BH, Nyakarahuka L, Sealy TK, Balinandi S, et al. (July 2015). "A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in Rousettus aegyptiacus Fruit Bats at Multiple Locations in Uganda". Journal of Wildlife Diseases. 51 (3): 774–9. doi:10.7589/2015-02-044. PMC 5022529. PMID 25919464.
Welch SR, Chakrabarti AK, Wiggleton Guerrero L, Jenks HM, Lo MK, Nichol ST, et al. (March 2018). "Development of a reverse genetics system for Sosuga virus allows rapid screening of antiviral compounds". PLoS Neglected Tropical Diseases. 12 (3): e0006326. doi:10.1371/journal.pntd.0006326. PMC 5862516. PMID 29522528.

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[2018.011M-1] Balkema-Buschmann, Anne; et al. (6 June 2018). "Re-organization of the family Paramyxoviridae" (xls). International Committee on Taxonomy of Viruses. Retrieved 22 September 2019.

[2] Albariño CG, Foltzer M, Towner JS, Rowe LA, Campbell S, Jaramillo CM, et al. (February 2014). "Novel paramyxovirus associated with severe acute febrile disease, South Sudan and Uganda, 2012". Emerging Infectious Diseases. 20 (2): 211–6. doi:10.3201/eid2002.131620. PMC 3901491. PMID 24447466.

[3] Amman BR, Albariño CG, Bird BH, Nyakarahuka L, Sealy TK, Balinandi S, et al. (July 2015). "A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in Rousettus aegyptiacus Fruit Bats at Multiple Locations in Uganda". Journal of Wildlife Diseases. 51 (3): 774–9. doi:10.7589/2015-02-044. PMC 5022529. PMID 25919464.

[4] Welch SR, Chakrabarti AK, Wiggleton Guerrero L, Jenks HM, Lo MK, Nichol ST, et al. (March 2018). "Development of a reverse genetics system for Sosuga virus allows rapid screening of antiviral compounds". PLoS Neglected Tropical Diseases. 12 (3): e0006326. doi:10.1371/journal.pntd.0006326. PMC 5862516. PMID 29522528.