Solute carrier family 38 member 9

Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. [5]

SLC38A9
Identifiers
Aliases	SLC38A9, URLC11, solute carrier family 38 member 9
External IDs	OMIM: 616203 MGI: 1918839 HomoloGene: 18139 GeneCards: SLC38A9
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,625,845 bp[1] End 55,773,194 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 112,660,751 bp[2] End 112,738,749 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • amino acid transmembrane transporter activity • L-leucine transmembrane transporter activity • GO:0015598 L-arginine transmembrane transporter activity • metal ion binding Cellular component • integral component of membrane • endosome • Ragulator complex • late endosome • lysosome • membrane • late endosome membrane • nucleoplasm • intracellular membrane-bounded organelle • lysosomal membrane • integral component of lysosomal membrane Biological process • cellular response to amino acid stimulus • amino acid transmembrane transport • amino acid transport • positive regulation of TOR signaling • cell cycle arrest • regulation of macroautophagy • branched-chain amino acid transport • neutral amino acid transport • cation transmembrane transport • L-alpha-amino acid transmembrane transport • L-arginine transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	153129	268706
Ensembl	ENSG00000177058	ENSMUSG00000047789
UniProt	Q8NBW4	Q8BGD6
RefSeq (mRNA)	NM_001258286 NM_001258287 NM_001282429 NM_173514 NM_001349382 NM_001349383 NM_001349384 NM_001349385	NM_175376 NM_178746
RefSeq (protein)	NP_001245215 NP_001245216 NP_001269358 NP_775785 NP_001336311 NP_001336312 NP_001336313 NP_001336314	NP_848861
Location (UCSC)	Chr 5: 55.63 – 55.77 Mb	Chr 13: 112.66 – 112.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000177058 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047789 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 38 member 9". Retrieved 2018-08-06.

Further reading

• Uchiyama K, Takagi T, Iwamoto Y, Kondo N, Okayama T, Yoshida N, Kamada K, Katada K, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Yagi N, Naito Y, Itoh Y (2014). "New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid". PLoS ONE. 9 (4): e95080. doi:10.1371/journal.pone.0095080. PMC 3999094. PMID 24762746.
• Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G (March 2015). "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477–81. doi:10.1038/nature14107. PMC 4376665. PMID 25561175.
• Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM (January 2015). "Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1". Science. 347 (6218): 188–94. doi:10.1126/science.1257132. PMC 4295826. PMID 25567906.
• Jung J, Genau HM, Behrends C (July 2015). "Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9". Mol. Cell. Biol. 35 (14): 2479–94. doi:10.1128/MCB.00125-15. PMC 4475919. PMID 25963655.