Small nucleolar RNA TBR12

Small nucleolar RNA TBR12 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoTBR12
Predicted secondary structure and sequence conservation of Small nucleolar RNA TBR12
Identifiers
RfamRF02789
Other data
Domain(s)Eukaryota
GO0006396,0005730
SO0000593
PDB structuresPDBe

snoRNA TBR12 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family direct site-specific 2'-O-methylation of substrate RNAs.[1]

TBR12 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies.[2] Together with TBR4, TBR6 and TBR2 it is a part of snoRNA gene cluster that is tandemly repeated. These 4 snoRNA genes are transcribed as a polycistronic RNA transcript.[3]

Other snoRNAs
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References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (May 2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". The Journal of Biological Chemistry. 275 (19): 14767–76. doi:10.1074/jbc.m001180200. PMID 10747997.
  3. Dunbar DA, Chen AA, Wormsley S, Baserga SJ (August 2000). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–61. doi:10.1093/nar/28.15.2855. PMC 102681. PMID 10908346.
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