Ski complex

The Ski complex is a multi-protein complex involved in the 3' end degradation of messenger RNAs in yeast.[1] The complex consists of three main proteins, the RNA helicase Ski2 and the proteins Ski3 and Ski8. In yeast, the complex guides RNA molecules to the exosome complex for degradation via a fourth protein, called Ski7, which contains a GTPase-like protein.[2]

See also

TRAMP complex
Non-stop decay
Nonsense mediated decay

References

Araki; Takahashi, S; Kobayashi, T; Kajiho, H; Hoshino, S; Katada, T; et al. (2001). "Ski7p G protein interacts with the exosome and the Ski complex for 3′-to-5′ mRNA decay in yeast". EMBO Journal. 20 (17): 4684–93. doi:10.1093/emboj/20.17.4684. PMC 125587. PMID 11532933.
Wang; Lewis, MS; Johnson, AW; et al. (2005). "Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p". RNA. 11 (8): 1291–302. doi:10.1261/rna.2060405. PMC 1370812. PMID 16043509.

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