Sialic acid acetylesterase

Sialic acid acetylesterase (SIAE) is an enzyme that produces 9-O acetylated sialic acid e.g. in mammals. It down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance e.g. in mice.[1]

Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.[1]

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