Scioderm

Scioderm, acquired by Amicus Therapeutics in 2015, was a rare disease company focused on developing a treatment for Epidermolysis Bullosa (EB), a rare genetic disease characterized by extremely fragile skin and recurrent blister formation. There are currently no approved therapies for EB. Scioderm was developing a topical treatment known as SD-101, or Zorblisa, aimed at triggering wound reduction and closure, and a reduction in body surface area coverage of blisters and lesions.[1]

Scioderm
IndustryPharmaceuticals
FoundedApril 2013 (2013-04)
FoundersRobert Coull, CA, CBV
Robert Ryan, Ph.D.
Headquarters
Durham, North Carolina
ProductsSD-101 for epidermolysis bullosa (EB)
BrandsZorblisa

Epidermolysis Bullosa, sometimes referred to as "Butterfly Skin",[2] is a rare genetic connective tissue disorder that, in all forms, results in extremely fragile skin that blisters or tears at the slightest friction or trauma.[3] EB typically manifests at birth or early childhood.[4] According to the Dystrophic Epidermolysis Bullosa Research Association of America (DEBRA), an estimated 1 out of every 20,000 live births are affected with some type of EB and the disorder occurs in every racial and ethnic group throughout the world and affects both sexes equally.[5]

In Scioderm's initial open-label Phase 2 study conducted in children with either Simplex, Recessive Dystrophic (RDEB), or Junctional EB, the application of SD-101 resulted in complete closure of 88% of target chronic lesions within one month, in addition to a 57% reduction in Body Surface Area (BSA) coverage of lesions and erosions after 3 months of daily treatment.[6][7]

SD-101, now owned by Amicus Therapeutics, is currently in Phase 3 clinical development to evaluate Zorblisa as a therapy for the treatment of lesions and blistering associated with Epidermolysis Bullosa.[8] Zorblisa is the first drug to ever enter Phase 3 development for the treatment of EB.[1] Stem cell research for Epidermolysis Bullosa is also underway by researchers at the University of Minnesota pursuant to an open-label Phase 2 trial.[9]

In April 2013 Scioderm received Breakthrough Therapy designation from the U.S. Food and Drug Administration (FDA) for its topical treatment, SD-101 for Epidermolysis Bullosa.[7] As a result of receiving Breakthrough therapy designation for SD-101, Scioderm was named a 2013 "Fierce Top 15" company by FierceBiotech.[10][11] Prior to Scioderm's receipt of the FDA's Breakthrough therapy designation for SD-101, it had only been given to high-profile pharmaceutical companies such as Johnson & Johnson, Merck and Novartis.[12] In addition to Breakthrough therapy designation, Scioderm received Orphan Drug Designation from both the FDA and from the European Medicines Agency (EMA) for its EB treatment.[13]

History

Scioderm was co-founded by Robert Coull and Robert Ryan.[14][15][16] Coull and Ryan "acquired the asset from another firm, which had demonstrated a wound healing effect at a lower concentration of the active ingredient before the topical [treatment's] advancement was stalled by lack of funding."[16] In April 2013, the company received $16 million in Series A Financing from Morgenthaler Ventures and Technology Partners.[17]

On August 31, 2015, Amicus Therapeutics announced the acquisition of Scioderm in a deal valued at approximately $950 million based on the achievement of certain milestones.[18][19] Amicus plans to complete the clinical development of SD-101 and to make the treatment commercially available for all EB patients as quickly as possible.[18]

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References
  1. Hein, Alexandria (28 July 2015). "Family of NYC girl with skin-blistering condition sees hope in new drug". FoxNews.com.
  2. Lupkin, Sydney (22 February 2013). "People with 'Butterfly' Skin Condition Triumph Through Pain". Good Morning America.
  3. Nichols, Laura (18 March 2014). "Biopharma company Scioderm chooses Clearpath as its agency partner". PR WEEK.
  4. "About". sderm.com. Scioderm.
  5. "Understanding EB". debra.org. DEBRA.
  6. "Scioderm's Investigational New Drug (IND) Application for SD-101 for Treatment of Epidermolysis Bullosa (EB) Allowed by the FDA" (Press release). Scioderm. BioSpace. 14 February 2013.
  7. "Scioderm's SD-101 Receives Breakthrough Therapy Designation from FDA for Treatment of Epidermolysis Bullosa" (PDF). sderm.com (Press release). Scioderm. 29 April 2013.
  8. "DEBRA Current Research Trials". debra.org. DEBRA.
  9. "Stem Cell Transplants for Epidermolysis Bullosa". ClinicalTrials.gov.
  10. Carroll, John (24 September 2013). "Scioderm - 2013 Fierce 15". FierceBiotech.
  11. Carroll, John (24 September 2013). "FierceBiotech's 2013 Fierce 15". FierceBiotech.
  12. Carroll, John (30 April 2013). "Biotech upstart joins Big-Pharma cast on high profile 'breakthrough' stage". FierceBiotech.
  13. "Scioderm To Present Data From Phase 2b Study Of Zorblisa (SD-101) At The Debra International Congress" (PDF). sderm.com (Press release). Scioderm. 9 September 2014.
  14. deBruyn, Jason (2 April 2014). "Scioderm close to fully developing new treatment for connective tissue disorder". Triangle Business Journal.
  15. "Life Sciences Awards - Robert Ryan". Triangle Business Journal. 23 May 2014.
  16. Boggs, Jennifer (21 April 2014). "Scioderm seeks fast track with breakthrough drug for rare skin disorder". Bioworld Today.(subscription required)
  17. "Scioderm Closes $16 Million in Series A Financing". pehub.com (Press release). PE HUB. 26 April 2013.
  18. "Amicus Therapeutics (FOLD) to acquire Scioderm in ~$950M deal". Streetinsider.com. 31 August 2015.
  19. Carroll, John (31 August 2015). "Amicus bags PhIII rare disease drug in $847M Scioderm buyout". FierceBiotech.
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