Scianna antigen system

The Scianna blood antigen system consists of seven antigens.[1][2] These include two high frequency antigens Sc1 and Sc3, and two low frequency antigens Sc2 and Sc4.[1]

The very rare null phenotype is characterised by the absence of Sc1, Sc2 and Sc3.[1]

The antigens are caused by changes in the erythroid membrane associated protein (ERMAP).[3][4]

History

This blood group system was discovered in 1962 when a high frequency antigen was detected in a young woman (Ms. Scianna) who had experienced several late pregnancy losses due to haemolytic disease of the fetus.[3]  

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References
  1. "Scianna Blood Group System", Human Blood Groups, Wiley-Blackwell, 2013-01-28, pp. 371–375, doi:10.1002/9781118493595.ch13, ISBN 9781118493595
  2. "Table of blood group systems" (PDF). ISBT. Retrieved 24 June 2019.
  3. Brunker, Patricia; Flegel, Willy (2011). "Scianna: the lucky 13th blood group system". Immunohematology. 27 (2): 41–57. PMC 5189634. PMID 22356519.
  4. Wagner, F. F.; Poole, Joyce; Flegel, Willy (2003-01-15). "Scianna antigens including Rd are expressed by ERMAP". Blood. 101 (2): 752–757. doi:10.1182/blood-2002-07-2064. PMID 12393480.
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