Salcatonin
Salcatonin is the type of calcitonin hormone found in salmon.[1]
As in humans, salmon calcitonin is a peptide hormone secreted by the parafollicular cells of the thyroid gland in response to hypercalcemia, and lowers blood calcium and phosphate by promoting renal excretion.
Therapeutic usage
Synthetic salmon calcitonin may be used therapeutically in humans, as it is twenty times more active than human calcitonin and has a longer half-life. It is used as therapy for Paget's disease and severe hypercalcemia. It is also used as a therapy against osteoporosis (working as an inhibitor of osteoclastic resorption), having an effectiveness of 40-50 times that of the human analogue.[1]
References
- Plosker, GL; McTavish, D (1996). "Intranasal salcatonin (salmon calcitonin). A review of its pharmacological properties and role in the management of postmenopausal osteoporosis". Drugs & Aging. 8 (5): 378–400. doi:10.2165/00002512-199608050-00006. PMID 8935399.
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