SULT1E1

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.[5][6]

SULT1E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G3M, 1HY3, 4JVL, 4JVM, 4JVN
Identifiers
Aliases	SULT1E1, EST, EST-1, ST1E1, STE, sulfotransferase family 1E member 1
External IDs	OMIM: 600043 MGI: 98431 HomoloGene: 101388 GeneCards: SULT1E1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 69,841,212 bp[1] End 69,860,145 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 43.56 cM Start 87,575,969 bp[2] End 87,591,594 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • estrone sulfotransferase activity • transferase activity • sulfotransferase activity • steroid binding • steroid sulfotransferase activity • flavonol 3-sulfotransferase activity • GO:0001948 protein binding • lipid binding • aryl sulfotransferase activity Cellular component • cytoplasm • cytosol • nuclear membrane Biological process • steroid metabolic process • positive regulation of fat cell differentiation • estrogen metabolic process • sulfation • ethanol catabolic process • estrogen catabolic process • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6783	20860
Ensembl	ENSG00000109193	ENSMUSG00000029272
UniProt	P49888	P49891 Q9D566
RefSeq (mRNA)	NM_005420	NM_023135
RefSeq (protein)	NP_005411	NP_075624
Location (UCSC)	Chr 4: 69.84 – 69.86 Mb	Chr 5: 87.58 – 87.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.[6]

See also

• Steroidogenic enzyme
• Steroid sulfotransferase
• Estrone sulfotransferase
• Steroid sulfatase

References

1. GRCh38: Ensembl release 89: ENSG00000109193 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029272 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bernier F, Leblanc G, Labrie F, Luu-The V (Dec 1994). "Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene". J Biol Chem. 269 (45): 28200–5. PMID 7961757.
6. "Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112-113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Falany CN, Krasnykh V, Falany JL (1995). "Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase". J. Steroid Biochem. Mol. Biol. 52 (6): 529–39. doi:10.1016/0960-0760(95)00015-R. PMID 7779757.
• Aksoy IA, Wood TC, Weinshilboum R (1994). "Human liver estrogen sulfotransferase: identification by cDNA cloning and expression". Biochem. Biophys. Res. Commun. 200 (3): 1621–9. doi:10.1006/bbrc.1994.1637. PMID 8185618.
• Her C, Aksoy IA, Kimura S, et al. (1996). "Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization". Genomics. 29 (1): 16–23. doi:10.1006/geno.1995.1210. PMID 8530066.
• Falany JL, Falany CN (1996). "Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines". Cancer Res. 56 (7): 1551–5. PMID 8603401.
• Her C, Szumlanski C, Aksoy IA, Weinshilboum RM (1997). "Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation". Drug Metab. Dispos. 24 (12): 1328–35. PMID 8971138.
• Song WC, Qian Y, Sun X, Negishi M (1997). "Cellular localization and regulation of expression of testicular estrogen sulfotransferase". Endocrinology. 138 (11): 5006–12. doi:10.1210/en.138.11.5006. PMID 9348232.
• Rubin GL, Harrold AJ, Mills JA, et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy". Mol. Hum. Reprod. 5 (11): 995–1002. doi:10.1093/molehr/5.11.995. PMID 10541560.
• Meinl W, Glatt H (2001). "Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene". Biochem. Biophys. Res. Commun. 288 (4): 855–62. doi:10.1006/bbrc.2001.5829. PMID 11688987.
• Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M (2002). "Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction". J. Biol. Chem. 277 (20): 17928–32. doi:10.1074/jbc.M111651200. PMID 11884392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M (2003). "Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase". Environ. Health Perspect. 111 (7): 884–8. doi:10.1289/ehp.6056. PMC 1241520. PMID 12782487.