STK25

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.[5][6][7][8]

STK25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XIK, 3W8H, 4NZW
Identifiers
Aliases	STK25, SOK1, YSK1, serine/threonine kinase 25
External IDs	OMIM: 602255 MGI: 1891699 HomoloGene: 48428 GeneCards: STK25
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,492,670 bp[1] End 241,509,730 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 D|1 47.25 cM Start 93,619,751 bp[2] End 93,658,659 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein homodimerization activity • metal ion binding • kinase activity • GO:0001948 protein binding • ATP binding • protein serine/threonine kinase activity • MAP kinase kinase kinase kinase activity Cellular component • cytoplasm • Golgi apparatus • Golgi membrane • extracellular exosome Biological process • intrinsic apoptotic signaling pathway in response to hydrogen peroxide • phosphorylation • response to oxidative stress • positive regulation of axonogenesis • establishment of Golgi localization • Golgi reassembly • establishment or maintenance of cell polarity • protein phosphorylation • Golgi localization • autophosphorylation • response to hydrogen peroxide • signal transduction • positive regulation of stress-activated MAPK cascade • MAPK cascade • activation of MAPKKK activity • regulation of mitotic cell cycle • regulation of apoptotic process • neuron projection morphogenesis • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10494	59041
Ensembl	ENSG00000115694	ENSMUSG00000026277
UniProt	O00506	Q9Z2W1
RefSeq (mRNA)	NM_001271977 NM_001271978 NM_001271979 NM_001271980 NM_001282305 NM_001282306 NM_001282307 NM_001282308 NM_006374	NM_021537
RefSeq (protein)	NP_001258906 NP_001258907 NP_001258908 NP_001258909 NP_001269234 NP_001269235 NP_001269236 NP_001269237 NP_006365	NP_067512
Location (UCSC)	Chr 2: 241.49 – 241.51 Mb	Chr 1: 93.62 – 93.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STK25 has been shown to interact with STRN,[9] PDCD10[10] and MOBKL3.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000115694 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026277 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J. 15 (17): 4537–46. PMC 452183. PMID 8887545.
6. Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885.
7. Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
8. "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".
9. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
10. Rual JF, Venkatesan K, Hao T, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Findlay GM, Yan L, Procter J, et al. (2007). "A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling". Biochem. J. 403 (1): 13–20. doi:10.1042/BJ20061881. PMC 1828895. PMID 17253963.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW (November 2010). "Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment". Cell. 143 (5): 826–36. doi:10.1016/j.cell.2010.10.029. PMC 3033572. PMID 21111240.