STK17A

STK17A
Identifiers
Aliases	STK17A, DRAK1, serine/threonine kinase 17a
External IDs	OMIM: 604726 HomoloGene: 55846 GeneCards: STK17A
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	43,650,713 bp[1]
Gene ontology
Molecular function	• kinase activity; • transferase activity; • nucleotide binding; • protein kinase activity; • protein serine/threonine kinase activity; • ATP binding;
Cellular component	• cell nucleus; • cell membrane; • nuclear speck;
Biological process	• positive regulation of apoptotic process; • positive regulation of fibroblast apoptotic process; • protein phosphorylation; • GO:0007243 intracellular signal transduction; • regulation of reactive oxygen species metabolic process; • phosphorylation; • apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9263
	n/a
	ENSG00000164543
	n/a
	Q9UEE5
	n/a
	NM_004760
	n/a
	NP_004751
	n/a
	Wikidata
View/Edit Human

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.[3]

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.[3]

gollark: Although until Ice Lake it's not fully fixed-function.

gollark: VP9 decode since Skylake or so and encode since Kaby Lake.

gollark: AV1 decode acceleration, I mean.

gollark: Intel has had it since Tiger Lake.

gollark: I think most codecs have a lossless mode but the size probably won't vary much.

References

GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Serine/threonine kinase 17a".

Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLoS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Serine/threonine kinase 17a".

STK17A

Function

References

Further reading