STAG1

STAG1
Identifiers
Aliases	STAG1, SA1, SCC3A, stromal antigen 1, MRD47
External IDs	OMIM: 604358 MGI: 1098658 HomoloGene: 21191 GeneCards: STAG1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	136,752,403 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	100,959,375 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • GO:0001948 protein binding;
Cellular component	• chromosome; • cytosol; • chromatin; • chromosome, centromeric region; • cell nucleus; • nucleoplasm; • nuclear body; • cohesin complex; • nuclear matrix; • mitotic spindle pole;
Biological process	• chromosome segregation; • cell division; • cell cycle; • transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • regulation of mitotic spindle assembly; • sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	10274
	20842
	ENSG00000118007
	ENSMUSG00000037286
	Q8WVM7
	Q9D3E6
	NM_005862
	NM_009282; NM_001357264; NM_001357265
	NP_005853
	NP_033308; NP_001344193; NP_001344194
	Wikidata
View/Edit Human	View/Edit Mouse

Cohesin subunit SA-1 (SA1) is a protein that in humans is encoded by the STAG1 gene.[5][6] SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

Structure of SA2 (blue) and RAD21 (green) (PDB 4PK7)

Structure and Interactions

SA1 is one of three human homologues of the yeast protein Scc3 which is a core subunit of the cohesin complex (the three human paralogues are SA1, SA2 and SA3). SA1 and SA2 are expressed in somatic cells whereas SA3 is the main SA paralogue in meiotic cells. SA1 stably binds to cohesin via the RAD21 subunit and functions as a platform for other regulatory subunits. SA1 has roles in regulating both cohesin loading and release. [6]

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References

GRCh38: Ensembl release 89: ENSG00000118007 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037286 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
"Entrez Gene: STAG1 stromal antigen 1".

External links

STAG1 human gene location in the UCSC Genome Browser.
STAG1 human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118007 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037286 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9305759-5] Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.

[entrez-6] "Entrez Gene: STAG1 stromal antigen 1".