STAB2

Function

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on liver sinusoidal endothelial cells, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.[7]

gollark: Ah, applied principle of explosion.
gollark: And both seem like a reasonable response to "people will be eternally tortured if they do not do this".
gollark: I don't *agree* with religious evangelism, I'm saying that it does not seem inconsistent with "true Catholicism" as qh4os says.
gollark: How? Consistently, if you believe that people not believing your thing will go to hell, and hell is bad, you should probably tell them. I'm not sure exactly what Catholic doctrine wrt. that *is* though, I think it varies.
gollark: And our experiments with understanding the underlying ethical particles have been halted after it transpired that colliding ethical entities at 99.99% of *c* actually had ethical associations itself, which caused bad interference.

References
  1. GRCh38: Ensembl release 89: ENSG00000136011 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035459 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S (February 2002). "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues". The Biochemical Journal. 362 (Pt 1): 155–64. doi:10.1042/0264-6021:3620155. PMC 1222372. PMID 11829752.
  6. Adachi H, Tsujimoto M (September 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". The Journal of Biological Chemistry. 277 (37): 34264–70. doi:10.1074/jbc.M204277200. PMID 12077138.
  7. "Entrez Gene: STAB2 stabilin 2".

Further reading
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