ST8SIA6

ST8SIA6
Identifiers
Aliases	ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139 MGI: 2386797 HomoloGene: 17112 GeneCards: ST8SIA6
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	17,454,330 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	13,794,064 bp[2]
Gene ontology
Molecular function	• transferase activity; • sialyltransferase activity; • transferase activity, transferring glycosyl groups; • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;
Cellular component	• integral component of membrane; • Golgi membrane; • Golgi apparatus; • membrane;
Biological process	• glycolipid biosynthetic process; • sialylation; • protein glycosylation; • protein O-linked glycosylation; • glycoprotein metabolic process; • oligosaccharide metabolic process; • ganglioside biosynthetic process; • carbohydrate biosynthetic process; • blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	338596
	241230
	ENSG00000148488
	ENSMUSG00000003418
	P61647
	Q8K4T1
	NM_001004470; NM_001345961
	NM_145838
	NP_001004470; NP_001332890
	NP_665837
	Wikidata
View/Edit Human	View/Edit Mouse

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. [5]

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

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References

GRCh38: Ensembl release 89: ENSG00000148488 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000003418 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37: 210–270. doi:10.1002/med.21407. PMID 27678392.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148488 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003418 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

ST8SIA6

Function

References

Further reading