SSX6

SSX6P
Identifiers
Aliases	SSX6P, SSXP2, dJ54B20.1, psiSSX2, synovial sarcoma, X breakpoint 6 (pseudogene), SSX family member 6, pseudogene, SSX6
External IDs	OMIM: 300541 GeneCards: SSX6P
Orthologs
	280657
	n/a
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	NM_173357
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	Wikidata
View/Edit Human

SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene. [2]

Function

This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy.

SSX1, SSX2, and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene is classified as a pseudogene because a splice donor in the 3' UTR has changed compared to other family members, rendering the transcript a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Aug 2009].

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References

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SSX family member 6, pseudogene". Retrieved 2017-12-11.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] "Entrez Gene: SSX family member 6, pseudogene". Retrieved 2017-12-11.