SSBP1

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene.[5][6]

SSBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S3O, 2DUD, 3ULL
Identifiers
Aliases	SSBP1, Mt-SSB, SOSS-B1, SSBP, mtSSB, single stranded DNA binding protein 1
External IDs	OMIM: 600439 MGI: 1920040 HomoloGene: 74462 GeneCards: SSBP1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 141,738,334 bp[1] End 141,787,922 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 40,471,352 bp[2] End 40,484,700 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • single-stranded DNA binding • chromatin binding • GO:0001948 protein binding • RNA binding Cellular component • mitochondrial matrix • mitochondrial nucleoid • extracellular exosome • mitochondrion • cell nucleus • nucleoid Biological process • DNA replication • mitochondrion organization • mitochondrion morphogenesis • positive regulation of helicase activity • mitochondrial DNA replication Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6742	381760
Ensembl	ENSG00000262771 ENSG00000106028	ENSMUSG00000029911
UniProt	Q04837	Q9CYR0
RefSeq (mRNA)	NM_001256510 NM_001256511 NM_001256512 NM_001256513 NM_003143	NM_001286663 NM_028358 NM_212468 NM_001364578
RefSeq (protein)	NP_001243439 NP_001243440 NP_001243441 NP_001243442 NP_003134	NP_001273592 NP_082634 NP_997633 NP_001351507
Location (UCSC)	Chr 7: 141.74 – 141.79 Mb	Chr 6: 40.47 – 40.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SSBP 1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995).[supplied by OMIM][6]

See also

• SSBP4

References

1. ENSG00000106028 GRCh38: Ensembl release 89: ENSG00000262771, ENSG00000106028 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029911 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (January 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.
6. "Entrez Gene: SSBP1 single-stranded DNA binding protein 1".

Further reading

• Tiranti V, Rocchi M, DiDonato S, Zeviani M (April 1993). "Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB)". Gene. 126 (2): 219–25. doi:10.1016/0378-1119(93)90370-I. PMID 8482537.
• Yang C, Curth U, Urbanke C, Kang C (February 1997). "Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution". Nature Structural Biology. 4 (2): 153–7. doi:10.1038/nsb0297-153. PMID 9033597.
• Schultz RA, Swoap SJ, McDaniel LD, Zhang B, Koon EC, Garry DJ, Li K, Williams RS (February 1998). "Differential expression of mitochondrial DNA replication factors in mammalian tissues". The Journal of Biological Chemistry. 273 (6): 3447–51. doi:10.1074/jbc.273.6.3447. PMID 9452467.
• Spelbrink JN, Toivonen JM, Hakkaart GA, Kurkela JM, Cooper HM, Lehtinen SK, Lecrenier N, Back JW, Speijer D, Foury F, Jacobs HT (August 2000). "In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells". The Journal of Biological Chemistry. 275 (32): 24818–28. doi:10.1074/jbc.M000559200. PMID 10827171.
• Müller-Höcker J, Schäfer S, Li K (September 2001). "Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue". Applied Immunohistochemistry & Molecular Morphology. 9 (3): 276–80. doi:10.1097/00022744-200109000-00013. PMID 11556757.
• Takamatsu C, Umeda S, Ohsato T, Ohno T, Abe Y, Fukuoh A, Shinagawa H, Hamasaki N, Kang D (May 2002). "Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein". EMBO Reports. 3 (5): 451–6. doi:10.1093/embo-reports/kvf099. PMC 1084112. PMID 11964388.
• Chen L, Segal D, Hukriede NA, Podtelejnikov AV, Bayarsaihan D, Kennison JA, Ogryzko VV, Dawid IB, Westphal H (October 2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14320–5. doi:10.1073/pnas.212532399. PMC 137882. PMID 12381786.
• Diez-Tascón C, Dodds KG, Crawford AM (December 2002). "Linkage mapping of the ovine single-stranded DNA-binding protein 1 (SSBP1) using microsatellite marker OARCDT7". Animal Genetics. 33 (6): 468. doi:10.1046/j.1365-2052.2002.00938_1.x. PMID 12464025.
• Bayarsaihan D (September 2002). "SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1599 (1–2): 152–5. doi:10.1016/s1570-9639(02)00376-x. PMID 12479417.
• Pocernich CB, Poon HF, Boyd-Kimball D, Lynn BC, Nath A, Klein JB, Butterfield DA (February 2005). "Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat". Brain Research. Molecular Brain Research. 133 (2): 299–306. doi:10.1016/j.molbrainres.2004.10.024. PMID 15710247.