SS18

Protein SSXT is a protein that in humans is encoded by the SS18 gene.[5][6][7]

SS18
Identifiers
Aliases	SS18, SSXT, SYT, nBAF chromatin remodeling complex subunit, SS18 subunit of BAF chromatin remodeling complex
External IDs	OMIM: 600192 MGI: 107708 HomoloGene: 38080 GeneCards: SS18
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 26,016,253 bp[1] End 26,091,217 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 14,624,198 bp[2] End 14,682,914 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • ligand-dependent nuclear receptor transcription coactivator activity • GO:0001105 transcription coactivator activity Cellular component • cytoplasmic microtubule • npBAF complex • cell nucleus • SWI/SNF complex Biological process • ephrin receptor signaling pathway • GO:0007243 intracellular signal transduction • regulation of transcription, DNA-templated • cytoskeleton organization • microtubule cytoskeleton organization • response to drug • cell morphogenesis • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • neuronal stem cell population maintenance • positive regulation of transcription, DNA-templated • regulation of nucleic acid-templated transcription • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6760	268996
Ensembl	ENSG00000141380	ENSMUSG00000037013
UniProt	Q15532 Q4VAX0	Q62280
RefSeq (mRNA)	NM_001007559 NM_001308201 NM_005637	NM_001161369 NM_001161370 NM_001161371 NM_009280
RefSeq (protein)	NP_001007560 NP_001295130 NP_005628 NP_005628.2	NP_001154841 NP_001154842 NP_001154843 NP_033306
Location (UCSC)	Chr 18: 26.02 – 26.09 Mb	Chr 18: 14.62 – 14.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex.[8][9][10]

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.[11]

Interactions

SS18 has been shown to interact with:

• EP300,[12]
• MLLT10,[13]
• SMARCA2,[10] and
• SMARCB1.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000141380 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037013 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene. 9 (5): 1447–53. PMID 8152806.
6. Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320.
7. de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research. 112 (3–4): 222–6. doi:10.1159/000089874. PMID 16484776.
8. Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. doi:10.1371/journal.pone.0033834. PMC 3307773. PMID 22442726.
9. Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
10. Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256.
11. Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676.
12. Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi:10.1016/S0092-8674(00)00072-6. PMID 11030627.
13. de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.

Further reading

• Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (Dec 1995). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". The American Journal of Pathology. 147 (6): 1592–9. PMC 1869933. PMID 7495284.
• Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi:10.1093/hmg/6.9.1559. PMID 9285794.
• Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G (Apr 1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Human Molecular Genetics. 8 (4): 585–91. doi:10.1093/hmg/8.4.585. PMID 10072425.
• Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi:10.1016/S0092-8674(00)00072-6. PMID 11030627.
• Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S (Apr 2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". British Journal of Cancer. 84 (8): 1087–94. doi:10.1054/bjoc.2000.1710. PMC 2363857. PMID 11308259.
• Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O (May 2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene. 268 (1–2): 173–82. doi:10.1016/S0378-1119(01)00412-7. PMID 11368913.
• de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" (PDF). Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
• Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676.
• Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A (Aug 2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Experimental Cell Research. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256.
• Iwasaki T, Koibuchi N, Chin WW (Sep 2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology. 146 (9): 3892–9. doi:10.1210/en.2004-1513. PMID 15919756.
• Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M (Mar 2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". International Journal of Cancer. 118 (5): 1165–72. doi:10.1002/ijc.21475. PMID 16152617.
• Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Dec 2005). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". The Journal of Biological Chemistry. 280 (52): 42863–76. doi:10.1074/jbc.M502963200. PMID 16227627.
• Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S (Feb 2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene. 25 (7): 1042–52. doi:10.1038/sj.onc.1209143. PMID 16247461.