SRPX

Sushi repeat-containing protein SRPX is a protein that in humans is encoded by the SRPX gene.[5][6][7] Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin.[8]

SRPX
Identifiers
Aliases	SRPX, DRS, ETX1, HEL-S-83p, SRPX1, sushi repeat containing protein, X-linked, sushi repeat containing protein X-linked
External IDs	OMIM: 300187 MGI: 1858306 HomoloGene: 4598 GeneCards: SRPX
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.4 Start 38,149,336 bp[1] End 38,220,924 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 10,037,977 bp[2] End 10,117,709 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • extracellular matrix structural constituent Cellular component • autophagosome • cell surface • endoplasmic reticulum • membrane • collagen-containing extracellular matrix Biological process • autophagy • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • phagolysosome assembly • cell adhesion • negative regulation of cell proliferation involved in contact inhibition • response to endoplasmic reticulum stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8406	51795
Ensembl	ENSG00000101955	ENSMUSG00000090084
UniProt	P78539	Q9R0M3
RefSeq (mRNA)	NM_006307 NM_001170750 NM_001170751 NM_001170752	NM_016911 NM_001365087
RefSeq (protein)	NP_001164221 NP_001164222 NP_001164223 NP_006298	NP_058607 NP_001352016
Location (UCSC)	Chr X: 38.15 – 38.22 Mb	Chr X: 10.04 – 10.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000101955 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090084 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Jul 1996). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Hum Mol Genet. 4 (12): 2339–46. doi:10.1093/hmg/4.12.2339. PMID 8634708.
6. Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, et al. (Jul 1996). "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3)". Hum Mol Genet. 4 (12): 2347–53. doi:10.1093/hmg/4.12.2347. PMID 8634709.
7. "Entrez Gene: SRPX sushi-repeat-containing protein, X-linked".
8. Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Further reading

• Nangaku M, Shankland SJ, Kurokawa K, et al. (1997). "Cloning of a new human gene with short consensus repeats using the EST database". Immunogenetics. 46 (2): 99–103. doi:10.1007/s002510050247. PMID 9162095.
• Shimakage M, Takami K, Kodama K, et al. (2002). "Expression of drs mRNA in human lung adenocarcinomas". Hum. Pathol. 33 (6): 615–9. doi:10.1053/hupa.2002.125373. PMID 12152160.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Mukaisho K, Suo M, Shimakage M, et al. (2003). "Down-regulation of drs mRNA in colorectal neoplasms". Jpn. J. Cancer Res. 93 (8): 888–93. doi:10.1111/j.1349-7006.2002.tb01334.x. PMC 5927109. PMID 12716466.
• Kim CJ, Shimakage M, Kushima R, et al. (2003). "Down-regulation of drs mRNA in human prostate carcinomas". Hum. Pathol. 34 (7): 654–7. doi:10.1016/S0046-8177(03)00240-5. PMID 12874760.
• Tambe Y, Isono T, Haraguchi S, et al. (2004). "A novel apoptotic pathway induced by the drs tumor suppressor gene". Oncogene. 23 (17): 2977–87. doi:10.1038/sj.onc.1207419. PMID 15021917.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.