SR1 RNA

In molecular biology, the SR1 RNA is a small RNA (sRNA) produced by species of Bacillus and closely related bacteria.[1] It is a dual-function RNA which acts both as a protein-coding RNA and as a regulatory sRNA.

SR1 RNA is involved in the regulation of arginine catabolism. SR1 RNA binds to complementary stretches of ahrC mRNA (also known as argR and inhibits translation.[2][3] AhrC endodes an arginine repressor protein which represses synthesis of arginine biosynthetic enzymes and activates arginine catabolic enzymes via regulation of the rocABC and rocDEF operons.[4][5][6]

In addition to acting as a sRNA, SR1 also encodes a small peptide, SR1P. SR1P binds to glyceraldehyde-3-phosphate dehydrogenase (GapA) and stabilises the gapA operon mRNAs.[7]

SR1 expression is regulated by CcpA and CcpN.[8][9]

See also

References
  1. Gimpel, M; Preis, H; Barth, E; Gramzow, L; Brantl, S (Oct 13, 2012). "SR1--a small RNA with two remarkably conserved functions". Nucleic Acids Research. 40 (22): 11659–72. doi:10.1093/nar/gks895. PMC 3526287. PMID 23034808.
  2. Heidrich, N; Moll, I; Brantl, S (2007). "In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA". Nucleic Acids Research. 35 (13): 4331–46. doi:10.1093/nar/gkm439. PMC 1935000. PMID 17576690.
  3. Heidrich, N; Chinali, A; Gerth, U; Brantl, S (Oct 2006). "The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism". Molecular Microbiology. 62 (2): 520–36. doi:10.1111/j.1365-2958.2006.05384.x. PMID 17020585.
  4. North, AK; Smith, MC; Baumberg, S (Aug 1, 1989). "Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor". Gene. 80 (1): 29–38. doi:10.1016/0378-1119(89)90247-3. PMID 2507400.
  5. Czaplewski, L. G.; North, A. K.; Smith, M. C. M.; Baumberg, S.; Stockley, P. G. (January 1992). "Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis". Mol. Microbiol. 6 (2): 267–75. doi:10.1111/j.1365-2958.1992.tb02008.x. PMID 1312212.
  6. Dennis C, CA; Glykos, NM; Parsons, MR; Phillips, SE (Mar 2002). "The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis". Acta Crystallographica Section D. 58 (Pt 3): 421–30. doi:10.1107/s0907444901021692. PMID 11856827.
  7. Gimpel, M; Heidrich, N; Mäder, U; Krügel, H; Brantl, S (May 2010). "A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon" (PDF). Molecular Microbiology. 76 (4): 990–1009. doi:10.1111/j.1365-2958.2010.07158.x. PMID 20444087.
  8. Licht, A; Preis, S; Brantl, S (Oct 2005). "Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis". Molecular Microbiology. 58 (1): 189–206. doi:10.1111/j.1365-2958.2005.04810.x. PMID 16164558.
  9. Licht, Andreas; Brantl, Sabine (October 2009). "The transcriptional repressor CcpN from Bacillus subtilis uses different repression mechanisms at different promoters". Journal of Biological Chemistry. 284 (44): 30032–8. doi:10.1074/jbc.M109.033076. PMC 2781557. PMID 19726675.
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