SPZ1

Spermatogenic leucine zipper protein 1 is a protein that in humans is encoded by the SPZ1 gene.[5][6][7][8][9][10]

SPZ1
Identifiers
Aliases	SPZ1, NYD-TSP1, PPP1R148, spermatogenic leucine zipper 1, CILD38
External IDs	OMIM: 618068 MGI: 1930801 HomoloGene: 49934 GeneCards: SPZ1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 80,319,625 bp[1] End 80,321,842 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 92,574,636 bp[2] End 92,576,172 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cellular component • cytoplasm • cell nucleus Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84654	79401
Ensembl	ENSG00000164299	ENSMUSG00000046957
UniProt	Q9BXG8	Q99MY0
RefSeq (mRNA)	NM_032567	NM_030237
RefSeq (protein)	NP_115956	NP_084513
Location (UCSC)	Chr 5: 80.32 – 80.32 Mb	Chr 13: 92.57 – 92.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000164299 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046957 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476.
6. Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID 12778315.
7. Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.
8. Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.
9. Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (May 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.
10. "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5" (PDF). Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.