SPRR2A

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.[3][4]

SPRR2A
Identifiers
Aliases	SPRR2A, small proline rich protein 2A
External IDs	OMIM: 182267 HomoloGene: 130544 GeneCards: SPRR2A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,056,120 bp[1] End 153,057,512 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • structural molecule activity Cellular component • cytoplasm • cornified envelope • cytosol Biological process • peptide cross-linking • keratinization • keratinocyte differentiation • epidermis development • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6700	n/a
Ensembl	ENSG00000241794	n/a
UniProt	P35326	n/a
RefSeq (mRNA)	NM_005988	n/a
RefSeq (protein)	NP_005979	n/a
Location (UCSC)	Chr 1: 153.06 – 153.06 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000241794 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
4. "Entrez Gene: SPRR2A small proline-rich protein 2A".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Tong L, Corrales RM, Chen Z, et al. (2006). "Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium". Invest. Ophthalmol. Vis. Sci. 47 (5): 1938–46. doi:10.1167/iovs.05-1129. PMC 2906387. PMID 16639001.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hong SH, Nah HY, Lee JY, et al. (2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus". Mol. Cells. 17 (3): 477–84. PMID 15232223.
• Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. PMID 12624109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Fischer DF, van Drunen CM, Winkler GS, et al. (1999). "Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker". Nucleic Acids Res. 26 (23): 5288–94. doi:10.1093/nar/26.23.5288. PMC 147987. PMID 9826750.
• Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. doi:10.1074/jbc.272.3.2021. PMID 8999895.
• Fischer DF, Gibbs S, van De Putte P, Backendorf C (1996). "Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation". Mol. Cell. Biol. 16 (10): 5365–74. doi:10.1128/MCB.16.10.5365. PMC 231535. PMID 8816448.
• Gibbs S, Lohman F, Teubel W, et al. (1990). "Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes". Nucleic Acids Res. 18 (15): 4401–7. doi:10.1093/nar/18.15.4401. PMC 331257. PMID 2388825.