SPRR1B

Cornifin-B is a protein that in humans is encoded by the SPRR1B gene.[3][4][5]

SPRR1B
Identifiers
Aliases	SPRR1B, CORNIFIN, GADD33, SPRR1, SPR-IB, small proline rich protein 1B
External IDs	OMIM: 182266 HomoloGene: 105655 GeneCards: SPRR1B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,031,203 bp[1] End 153,032,900 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • structural molecule activity Cellular component • cornified envelope • cytosol • cytoplasm Biological process • keratinization • keratinocyte differentiation • epidermis development • peptide cross-linking • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6699	n/a
Ensembl	ENSG00000169469	n/a
UniProt	P22528	n/a
RefSeq (mRNA)	NM_003125	n/a
RefSeq (protein)	NP_003116	n/a
Location (UCSC)	Chr 1: 153.03 – 153.03 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000169469 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
4. Marvin KW, George MD, Fujimoto W, Saunders NA, Bernacki SH, Jetten AM (Dec 1992). "Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids". Proc Natl Acad Sci U S A. 89 (22): 11026–30. doi:10.1073/pnas.89.22.11026. PMC 50476. PMID 1438308.
5. "Entrez Gene: SPRR1B small proline-rich protein 1B (cornifin)".

Further reading

• Fornace AJ (1993). "Mammalian genes induced by radiation; activation of genes associated with growth control". Annu. Rev. Genet. 26: 507–26. doi:10.1146/annurev.ge.26.120192.002451. PMID 1482123.
• An G, Huang TH, Tesfaigzi J, et al. (1992). "An unusual expression of a squamous cell marker, small proline-rich protein gene, in tracheobronchial epithelium: differential regulation and gene mapping". Am. J. Respir. Cell Mol. Biol. 7 (1): 104–11. doi:10.1165/ajrcmb/7.1.104. PMID 1627333.
• Kartasova T, van de Putte P (1988). "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes". Mol. Cell. Biol. 8 (5): 2195–203. doi:10.1128/MCB.8.5.2195. PMC 363401. PMID 3133554.
• Greco MA, Lorand L, Lane WS, et al. (1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". J. Invest. Dermatol. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
• An G, Tesfaigzi J, Chuu YJ, Wu R (1993). "Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP". J. Biol. Chem. 268 (15): 10977–82. PMID 8388378.
• Austin SJ, Fujimoto W, Marvin KW, et al. (1996). "Cloning and regulation of cornifin beta, a new member of the cornifin/spr family. Suppression by retinoic acid receptor-selective retinoids". J. Biol. Chem. 271 (7): 3737–42. doi:10.1074/jbc.271.7.3737. PMID 8631988.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Robinson NA, Lapic S, Welter JF, Eckert RL (1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". J. Biol. Chem. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
• Lee CH, Marekov LN, Kim S, et al. (2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Lett. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733.
• Reddy SP, Adiseshaiah P, Shapiro P, Vuong H (2002). "BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells". Am. J. Respir. Cell Mol. Biol. 27 (1): 64–70. CiteSeerX 10.1.1.324.6191. doi:10.1165/ajrcmb.27.1.20020003oc. PMID 12091247.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tesfaigzi Y, Wright PS, Belinsky SA (2003). "SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (4): L889–98. doi:10.1152/ajplung.00065.2003. PMID 12832281.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.