SPINK6

Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14.[1] SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.[2]

See also
  • Kazal-type serine protease inhibitor domain

References
  1. Meyer-Hoffert U; Wu Z; Kantyka T; Fischer J; Latendorf T; Hansmann B; Bartels J; He Y; Gläser R; Schröder JM. (October 2010). "Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases". J Biol Chem. 285 (42): 32174–81. doi:10.1074/jbc.M109.091850. PMC 2952218. PMID 20667819.
  2. Furio L; Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.