SPDEF

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.[5][6][7]

SPDEF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPDEF, PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
External IDsOMIM: 608144 MGI: 1353422 HomoloGene: 8231 GeneCards: SPDEF
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.31Start34,537,802 bp[1]
End34,556,333 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25803

30051

Ensembl

ENSG00000124664

ENSMUSG00000024215

UniProt

O95238

Q9WTP3

RefSeq (mRNA)

NM_001252294
NM_012391

NM_013891
NM_001357728

RefSeq (protein)

NP_001239223
NP_036523

NP_038919
NP_001344657

Location (UCSC)Chr 6: 34.54 – 34.56 MbChr 17: 27.71 – 27.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM][7]

Interactions

SPDEF has been shown to interact with NKX3-1.[8]

The protein kinase CK2 has been shown to control the stability of PDEF.[9] Needed for the differentiation of both pulmonary and intestinal goblet cells.

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References

  1. GRCh38: Ensembl release 89: ENSG00000124664 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024215 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Oettgen P; Finger E; Sun Z; Akbarali Y; Thamrongsak U; Boltax J; Grall F; Dube A; Weiss A; Brown L; Quinn G; Kas K; Endress G; Kunsch C; Libermann TA (February 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem. 275 (2): 1216–25. doi:10.1074/jbc.275.2.1216. PMID 10625666.
  6. Johannessen JV; Finseth I (July 1983). "Electron micrographs in five minutes". Ultrastruct Pathol. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.
  7. "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".
  8. Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. United States. 62 (2): 338–40. ISSN 0008-5472. PMID 11809674.
  9. Chisholm, Christine; Padmanabhan Achuth; Guan Bin; Li Xiang; Kalra Simran; Bieberich Charles J (2010). "Protein Kinase CK2 regulates the stability of prostate derived Ets factor". The Open Cancer Journal. Bentham Science. 3: 109–115. doi:10.2174/1874079001003010109.http://www.benthamscience.com/open/tocj/articles/V003/SI0022TOCJ/109TOCJ.pdf

Further reading

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