SPC24

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.[5]

SPC24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VE7, 3IZ0
Identifiers
Aliases	SPC24, SPBC24, NDC80 kinetochore complex component, SPC24 component of NDC80 kinetochore complex
External IDs	OMIM: 609394 MGI: 1914879 HomoloGene: 12166 GeneCards: SPC24
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 11,131,520 bp[1] End 11,155,808 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,755,442 bp[2] End 21,760,303 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • condensed chromosome kinetochore • cytosol • Ndc80 complex • nucleolus • chromosome, centromeric region • cell nucleus • kinetochore • chromosome Biological process • cell division • cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147841	67629
Ensembl	ENSG00000161888	ENSMUSG00000074476
UniProt	Q8NBT2	Q9D083
RefSeq (mRNA)	NM_182513 NM_001317031 NM_001317032 NM_001317033	NM_026282 NM_001357331
RefSeq (protein)	NP_001303960 NP_001303961 NP_001303962 NP_872319	NP_080558 NP_001344260
Location (UCSC)	Chr 19: 11.13 – 11.16 Mb	Chr 9: 21.76 – 21.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000161888 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074476 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading

• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ (June 2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272.
• Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (August 2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". The Journal of Biological Chemistry. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
• Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
• McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT (January 2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Current Biology. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735.
• Bharadwaj R, Qi W, Yu H (March 2004). "Identification of two novel components of the human NDC80 kinetochore complex". The Journal of Biological Chemistry. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.