Sperm-associated antigen 5

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.[5][6]

SPAG5
Identifiers
Aliases	SPAG5, DEEPEST, MAP126, hMAP126, Sperm associated antigen 5
External IDs	OMIM: 615562 MGI: 1927470 HomoloGene: 4718 GeneCards: SPAG5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,577,565 bp[1] End 28,599,025 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,301,529 bp[2] End 78,322,457 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • microtubule binding Cellular component • spindle • mitotic spindle • chromosome • microtubule organizing center • centriolar satellite • condensed chromosome kinetochore • spindle pole • chromosome, centromeric region • microtubule plus-end • midbody • microtubule • kinetochore • cytoskeleton • cytoplasm • mitotic spindle pole • spindle microtubule Biological process • mitotic sister chromatid segregation • cell cycle • GO:0043146 spindle organization • cell division • protein localization to centrosome • chromosome segregation • regulation of attachment of spindle microtubules to kinetochore • positive regulation of intracellular transport • regulation of metaphase plate congression • positive regulation of spindle assembly • establishment of spindle orientation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10615	54141
Ensembl	ENSG00000076382	ENSMUSG00000002055
UniProt	Q96R06	Q7TME2
RefSeq (mRNA)	NM_006461	NM_017407
RefSeq (protein)	NP_006452	NP_059103
Location (UCSC)	Chr 17: 28.58 – 28.6 Mb	Chr 11: 78.3 – 78.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000076382 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002055 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC (Sep 2001). "Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins". Biochem Biophys Res Commun. 287 (1): 116–21. doi:10.1006/bbrc.2001.5554. PMID 11549262.
6. "Entrez Gene: SPAG5 sperm associated antigen 5".

Further reading

• Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
• Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–6. doi:10.1002/mrd.1047. PMID 11468777.
• Mack GJ, Compton DA (2002). "Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14434–9. doi:10.1073/pnas.261371298. PMC 64699. PMID 11724960.
• Gruber J, Harborth J, Schnabel J, et al. (2003). "The mitotic-spindle-associated protein astrin is essential for progression through mitosis". J. Cell Sci. 115 (Pt 21): 4053–9. doi:10.1242/jcs.00088. PMID 12356910.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
• Yang YC, Hsu YT, Wu CC, et al. (2006). "Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells". Biochem. Biophys. Res. Commun. 343 (2): 428–34. doi:10.1016/j.bbrc.2006.02.166. PMID 16546135.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Cheng TS, Hsiao YL, Lin CC, et al. (2007). "hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases". Exp. Cell Res. 313 (8): 1710–21. doi:10.1016/j.yexcr.2007.02.023. PMID 17383637.