SPA17

Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.[5][6]

SPA17
Identifiers
Aliases	SPA17, CT22, SP17, SP17-1, sperm autoantigenic protein 17
External IDs	OMIM: 608621 MGI: 1333778 HomoloGene: 7951 GeneCards: SPA17
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,673,798 bp[1] End 124,697,518 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 37,603,290 bp[2] End 37,613,722 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • calmodulin binding Cellular component • cytoplasm • sperm principal piece • motile cilium • sperm fibrous sheath • external side of plasma membrane • membrane • cilium • extracellular region Biological process • epithelial cilium movement • spermatogenesis • single fertilization • binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53340	20686
Ensembl	ENSG00000064199	ENSMUSG00000001948
UniProt	Q15506	Q62252
RefSeq (mRNA)	NM_017425	NM_011449 NM_001324545
RefSeq (protein)	NP_059121	NP_001311474 NP_035579
Location (UCSC)	Chr 11: 124.67 – 124.7 Mb	Chr 9: 37.6 – 37.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000064199 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001948 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta. 1307 (3): 263–6. doi:10.1016/0167-4781(96)00077-2. PMID 8688458.
6. "Entrez Gene: SPA17 sperm autoantigenic protein 17".

Further reading

• McLeskey SB, Dowds C, Carballada R, et al. (1997). Molecules involved in mammalian sperm-egg interaction. Int. Rev. Cytol. International Review of Cytology. 177. pp. 57–113. doi:10.1016/S0074-7696(08)62231-7. ISBN 9780123645814. PMID 9378618.
• Richardson RT, Yamasaki N, O'Rand MG (1994). "Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. doi:10.1006/dbio.1994.1285. PMID 7525387.
• Kong M, Richardson RT, Widgren EE, O'Rand MG (1995). "Sequence and localization of the mouse sperm autoantigenic protein, Sp17". Biol. Reprod. 53 (3): 579–90. doi:10.1095/biolreprod53.3.579. PMID 7578682.
• Fujita A, Nakamura K, Kato T, et al. (2000). "Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella". J. Cell Sci. 113 (1): 103–12. PMID 10591629.
• Wen Y, Richardson RT, Widgren EE, O'Rand MG (2001). "Characterization of Sp17: a ubiquitous three domain protein that binds heparin". Biochem. J. 357 (Pt 1): 25–31. doi:10.1042/0264-6021:3570025. PMC 1221924. PMID 11415432.
• De Jong A, Buchli R, Robbins D (2003). "Characterization of sperm protein 17 in human somatic and neoplastic tissue". Cancer Lett. 186 (2): 201–9. doi:10.1016/S0304-3835(02)00350-6. PMID 12213290.
• Buchli R, De Jong A, Robbins DL (2002). "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model". Biochim. Biophys. Acta. 1578 (1–3): 29–42. doi:10.1016/S0167-4781(02)00478-5. PMID 12393185.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding". Reproduction. 124 (6): 767–74. doi:10.1530/rep.0.1240767. PMID 12530914.
• Takeoka Y, Kenny TP, Yago H, et al. (2004). "Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes". Dev. Immunol. 9 (2): 97–102. doi:10.1080/1044667021000095186. PMC 2276097. PMID 12739786.
• Chiriva-Internati M, Wang Z, Pochopien S, et al. (2004). "Identification of a sperm protein 17 CTL epitope restricted by HLA-A1". Int. J. Cancer. 107 (5): 863–5. doi:10.1002/ijc.11486. PMID 14566839.
• Straughn JM, Shaw DR, Guerrero A, et al. (2004). "Expression of sperm protein 17 (Sp17) in ovarian cancer". Int. J. Cancer. 108 (6): 805–11. doi:10.1002/ijc.11617. PMID 14712480.
• Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. Biol. Endocrinol. 2: 57. doi:10.1186/1477-7827-2-57. PMC 484205. PMID 15257753.
• Wang Z, Zhang Y, Ramsahoye B, et al. (2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer. 91 (8): 1597–603. doi:10.1038/sj.bjc.6602160. PMC 2409933. PMID 15381930.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gupta G, Sharma R, Chattopadhyay TK, et al. (2007). "Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer". Int. J. Cancer. 120 (8): 1739–47. doi:10.1002/ijc.22463. PMID 17230514.