SOX17

SRY-box 17 is a protein that in humans is encoded by the SOX17 gene. [5]

SOX17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YUL, 4A3N
Identifiers
Aliases	SOX17, VUR3, SRY-box 17, SRY-box transcription factor 17
External IDs	OMIM: 610928 MGI: 107543 HomoloGene: 7948 GeneCards: SOX17
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.23 Start 54,457,935 bp[1] End 54,460,892 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A1|1 1.65 cM Start 4,490,931 bp[2] End 4,497,354 bp[2]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • beta-catenin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • transcription factor binding • GO:0001948 protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • transcription factor complex • nucleoplasm • cell nucleus Biological process • renal system development • endoderm development • regulation of embryonic development • regulation of transcription, DNA-templated • positive regulation of protein catabolic process • stem cell fate specification • positive regulation of skeletal muscle tissue development • embryonic foregut morphogenesis • regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification • embryonic organ development • endodermal digestive tract morphogenesis • negative regulation of mesodermal cell fate specification • inner cell mass cellular morphogenesis • negative regulation of Wnt signaling pathway • protein stabilization • endocardium formation • outflow tract morphogenesis • signal transduction involved in regulation of gene expression • endodermal cell fate determination • mRNA transcription from RNA polymerase II promoter • regulation of mesodermal cell fate specification • negative regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway • endocardial cell differentiation • regulation of cardiac cell fate specification • transcription, DNA-templated • stem cell differentiation • embryonic heart tube development • vasculogenesis • positive regulation of transcription, DNA-templated • heart looping • cardiac cell fate determination • common bile duct development • negative regulation of Wnt signaling pathway involved in heart development • rostrocaudal neural tube patterning • positive regulation of gene expression • cardiogenic plate morphogenesis • heart formation • embryonic heart tube morphogenesis • negative regulation of cell growth • protein destabilization • angiogenesis • spermatogenesis • positive regulation of cell differentiation • regulation of stem cell division • gastrulation • gall bladder development • canonical Wnt signaling pathway • regulation of cell differentiation • cell migration involved in gastrulation • endoderm formation • regulation of stem cell proliferation • negative regulation of canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • cellular response to leukemia inhibitory factor • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64321	20671
Ensembl	ENSG00000164736	ENSMUSG00000025902
UniProt	Q9H6I2	Q61473
RefSeq (mRNA)	NM_022454	NM_001289464 NM_001289465 NM_001289466 NM_001289467 NM_011441
RefSeq (protein)	NP_071899	NP_001276393 NP_001276394 NP_001276395 NP_001276396 NP_035571
Location (UCSC)	Chr 8: 54.46 – 54.46 Mb	Chr 1: 4.49 – 4.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

References

1. GRCh38: Ensembl release 89: ENSG00000164736 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025902 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SRY-box 17". Retrieved 2017-09-07.

Further reading

• Zhang W, Glöckner SC, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB (2008). "Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer". Cancer Res. 68 (8): 2764–72. doi:10.1158/0008-5472.CAN-07-6349. PMC 2823123. PMID 18413743.
• Patterson ES, Addis RC, Shamblott MJ, Gearhart JD (2008). "SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation". Physiol. Genomics. 34 (3): 277–84. doi:10.1152/physiolgenomics.90236.2008. PMID 18523156.
• Ferrell RE, Kimak MA, Lawrence EC, Finegold DN (2008). "Candidate gene analysis in primary lymphedema". Lymphat Res Biol. 6 (2): 69–76. doi:10.1089/lrb.2007.1022. PMID 18564921.
• Séguin CA, Draper JS, Nagy A, Rossant J (2008). "Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells". Cell Stem Cell. 3 (2): 182–95. doi:10.1016/j.stem.2008.06.018. PMID 18682240.
• Semb H (2008). "Expandable endodermal progenitors: new tools to explore endoderm and its derivatives". Cell Stem Cell. 3 (4): 355–6. doi:10.1016/j.stem.2008.09.010. PMID 18940723.
• Fu DY, Wang ZM, Li-Chen, Wang BL, Shen ZZ, Huang W, Shao ZM (2010). "Sox17, the canonical Wnt antagonist, is epigenetically inactivated by promoter methylation in human breast cancer". Breast Cancer Res. Treat. 119 (3): 601–12. doi:10.1007/s10549-009-0339-8. PMID 19301122.
• Nonaka D (2009). "Differential expression of SOX2 and SOX17 in testicular germ cell tumors". Am. J. Clin. Pathol. 131 (5): 731–6. doi:10.1309/AJCP7MNCNBCRN8NO. PMID 19369635.
• Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Kotani H, Taketo MM, Oshima M (2009). "Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis". Gastroenterology. 137 (4): 1346–57. doi:10.1053/j.gastro.2009.06.041. PMID 19549530.
• Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M (2009). "Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate". J. Cell Biol. 186 (5): 665–73. doi:10.1083/jcb.200901040. PMC 2742180. PMID 19736317.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.