SORBS3

Vinexin is a protein that in humans is encoded by the SORBS3 gene.[5][6][7]

SORBS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CT3, 2DLM, 2NWM, 2YUP
Identifiers
Aliases	SORBS3, SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
External IDs	OMIM: 610795 MGI: 700013 HomoloGene: 4218 GeneCards: SORBS3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,544,986 bp[1] End 22,575,788 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D2|14 36.27 cM Start 70,180,468 bp[2] End 70,211,989 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • vinculin binding • transcription factor binding • structural constituent of cytoskeleton • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • cell junction • cytoskeleton • cell nucleus • focal adhesion Biological process • cell-substrate adhesion • cell adhesion • muscle contraction • negative regulation of transcription from RNA polymerase II promoter • positive regulation of stress fiber assembly • positive regulation of cytoskeleton organization • positive regulation of MAPK cascade • actin filament organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10174	20410
Ensembl	ENSG00000120896	ENSMUSG00000022091
UniProt	O60504	Q9R1Z8
RefSeq (mRNA)	NM_001018003 NM_005775	NM_001271407 NM_001271408 NM_001271409 NM_011366
RefSeq (protein)	NP_001018003 NP_005766	NP_001258336 NP_001258337 NP_001258338 NP_035496
Location (UCSC)	Chr 8: 22.54 – 22.58 Mb	Chr 14: 70.18 – 70.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SORBS3 has been shown to interact with DLG5[8] and MAPK1.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000120896 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022091 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kioka N; Sakata S; Kawauchi T; Amachi T; Akiyama SK; Okazaki K; Yaen C; Yamada KM; Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC 2148117. PMID 9885244.
6. Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku. 74 (11): 1356–60. PMID 12510380.
7. "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
8. Wakabayashi, Makoto; Ito Takuya; Mitsushima Masaru; Aizawa Sanae; Ueda Kazumitsu; Amachi Teruo; Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. ISSN 0021-9258. PMID 12657639.
9. Mitsushima, Masaru; Suwa Akira; Amachi Teruo; Ueda Kazumitsu; Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi:10.1074/jbc.M402304200. ISSN 0021-9258. PMID 15184391.

Further reading

• Akamatsu M, Aota S, Suwa A, et al. (2000). "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities". J. Biol. Chem. 274 (50): 35933–7. doi:10.1074/jbc.274.50.35933. PMID 10585480.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wakabayashi M, Ito T, Mitsushima M, et al. (2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. PMID 12657639.
• Townson SM, Dobrzycka KM, Lee AV, et al. (2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
• Mitsushima M, Suwa A, Amachi T, et al. (2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi:10.1074/jbc.M402304200. PMID 15184391.
• Martens N, Wery M, Wang P, et al. (2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Exp. Cell Res. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bour G, Plassat JL, Bauer A, et al. (2005). "Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription". J. Biol. Chem. 280 (17): 17027–37. doi:10.1074/jbc.M501344200. PMID 15734736.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Mitsushima M; Ueda K; Kioka N (2006). "Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface". Genes Cells. 11 (9): 971–82. doi:10.1111/j.1365-2443.2006.00995.x. PMID 16923119.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Mizutani K, Ito H, Iwamoto I, et al. (2007). "Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth". Oncogene. 26 (50): 7122–31. doi:10.1038/sj.onc.1210512. PMID 17486060.

External links

• SORBS3 human gene location in the UCSC Genome Browser.
• SORBS3 human gene details in the UCSC Genome Browser.