SNAP91

Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the SNAP91 gene.[5][6][7][8]

SNAP91
Identifiers
Aliases	SNAP91, AP180, CALM, synaptosome associated protein 91kDa, synaptosome associated protein 91
External IDs	OMIM: 607923 MGI: 109132 HomoloGene: 8429 GeneCards: SNAP91
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.2 Start 83,552,880 bp[1] End 83,709,691 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.1 Start 86,765,923 bp[2] End 86,880,654 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • clathrin binding • 1-phosphatidylinositol binding • GO:0001948 protein binding • phospholipid binding • protein kinase binding • SNARE binding • phosphatidylinositol-4,5-bisphosphate binding • clathrin heavy chain binding Cellular component • cell membrane • clathrin-coated pit • membrane • clathrin-coated vesicle • synaptic vesicle • presynaptic membrane • extrinsic component of presynaptic endocytic zone membrane Biological process • clathrin coat assembly • protein transport • regulation of clathrin-dependent endocytosis • endocytosis • vesicle budding from membrane • synaptic vesicle budding from presynaptic endocytic zone membrane • synaptic vesicle endocytosis • clathrin-dependent endocytosis • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9892	20616
Ensembl	ENSG00000065609	ENSMUSG00000033419
UniProt	O60641	Q61548
RefSeq (mRNA)	NM_001242792 NM_001242793 NM_001242794 NM_001256717 NM_001256718 NM_014841 NM_001363677	NM_001277982 NM_001277983 NM_001277985 NM_001277986 NM_013669 NM_001357768 NM_001357770 NM_001357772
RefSeq (protein)	NP_001229721 NP_001229722 NP_001229723 NP_001243646 NP_001243647 NP_055656 NP_001350606 NP_001363604 NP_001363605 NP_001363606 NP_001363607 NP_001363608 NP_001363609 NP_001363610 NP_001363611 NP_001363612 NP_001363613 NP_001363614 NP_001363615 NP_001363616 NP_001363617 NP_001363618 NP_001363619 NP_001363620 NP_001363621 NP_001363622 NP_001363623 NP_001363624 NP_001363625 NP_001363626 NP_001363627 NP_001363628 NP_001363629 NP_001363630 NP_001363631 NP_001363632 NP_001363633 NP_001363634 NP_001363635 NP_001363636 NP_001363637 NP_001363638 NP_001363639 NP_001363640 NP_001363641 NP_001363642 NP_001363643 NP_001363644 NP_001363645 NP_001363646 NP_001363647 NP_001363648 NP_001363649 NP_001363650 NP_001363652 NP_001363655 NP_001363657 NP_001363660 NP_001363662 NP_001363663 NP_001363664 NP_001363665 NP_001363666 NP_001363667 NP_001363668 NP_001363669 NP_001363670 NP_001363671	NP_001264911 NP_001264912 NP_001264914 NP_001264915 NP_038697 NP_001344697 NP_001344699 NP_001344701
Location (UCSC)	Chr 6: 83.55 – 83.71 Mb	Chr 9: 86.77 – 86.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000065609 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033419 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
6. Yao PJ, O'Herron TM, Coleman PD (Dec 2002). "Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain". Neurobiology of Aging. 24 (1): 173–8. doi:10.1016/S0197-4580(02)00055-6. PMID 12493563.
7. Tebar F, Bohlander SK, Sorkin A (August 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Molecular Biology of the Cell. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. PMC 25500. PMID 10436022.
8. "Entrez Gene: SNAP91 synaptosomal-associated protein, 91kDa homolog (mouse)".

Further reading

• Murphy JE, Hanover JA, Froehlich M, DuBois G, Keen JH (August 1994). "Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain". The Journal of Biological Chemistry. 269 (33): 21346–52. PMID 8063760.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Traub LM, Downs MA, Westrich JL, Fremont DH (August 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 8907–12. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
• Yao PJ, Morsch R, Callahan LM, Coleman PD (1999). "Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry". Neuroscience. 94 (2): 389–94. doi:10.1016/S0306-4522(99)00360-7. PMID 10579202.
• Slepnev VI, Ochoa GC, Butler MH, De Camilli P (June 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". The Journal of Biological Chemistry. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
• Han SJ, Lee JH, Hong SH, Park SD, Kim CG, Song MD, Park TK, Kim CG (January 2002). "AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity". Biochemical and Biophysical Research Communications. 290 (1): 35–41. doi:10.1006/bbrc.2001.6154. PMID 11779129.
• Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (July 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry. 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.
• Hussain NK, Yamabhai M, Bhakar AL, Metzler M, Ferguson SS, Hayden MR, McPherson PS, Kay BK (August 2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". The Journal of Biological Chemistry. 278 (31): 28823–30. doi:10.1074/jbc.M300995200. PMID 12750376.
• Morgan JR, Prasad K, Jin S, Augustine GJ, Lafer EM (August 2003). "Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling". The Journal of Biological Chemistry. 278 (35): 33583–92. doi:10.1074/jbc.M304346200. PMID 12807910.
• Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V (July 2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma". The Journal of Cell Biology. 162 (1): 113–24. doi:10.1083/jcb.200301006. PMC 2172713. PMID 12847086.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Zhan X, Desiderio DM (December 2004). "The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry". Biochemical and Biophysical Research Communications. 325 (4): 1180–6. doi:10.1016/j.bbrc.2004.10.169. PMID 15555551.