SMCR7L

MIEF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NXT, 4NXU, 4NXV, 4NXW, 4NXX
Identifiers
Aliases	MIEF1, HSU79252, MID51, SMCR7L, dJ1104E15.3, mitochondrial elongation factor 1, AltMIEF1-MP
External IDs	OMIM: 615497 MGI: 2146020 HomoloGene: 10374 GeneCards: MIEF1
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	39,518,132 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	80,253,371 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • ADP binding; • GO:0001948 protein binding; • GDP binding; • identical protein binding;
Cellular component	• integral component of membrane; • mitochondrial outer membrane; • peroxisome; • membrane; • mitochondrion; • mitochondrial matrix; • mitochondrial large ribosomal subunit;
Biological process	• mitochondrial fusion; • positive regulation of mitochondrial fission; • mitochondrial fission; • positive regulation of protein targeting to membrane; • regulation of translation; • ribosome biogenesis; • positive regulation of mitochondrial translation;
	Sources:Amigo / QuickGO
Orthologs
	54471
	239555
	ENSG00000100335
	ENSMUSG00000022412
	L0R8F8
	Q8BGV8
	NM_001304564; NM_013298; NM_019008
	NM_178719; NM_001357659; NM_001357660
	NP_001291493; NP_061881
	NP_848834; NP_001344588; NP_001344589
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7L gene.[5][6][7]

Function

The SMCR7L gene codes for a protein that has been called MiD51/MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1.[8]

gollark: Well, I would *consider* it, but wouldn't want to be stuck in a stupidly immersive virtual world.

gollark: Well, there are various issues, really. Random bugs and stuff crashing your brain, random bugs allowing other people to meddle with your brain, things deliberately designed to give up data and whatnot...

gollark: Well, both are problems, really.

gollark: "Wow, this Facebook™ neural implant is free as long as I tick this option to send my thoughts to Facebook!"

gollark: Inevitably.

References

GRCh38: Ensembl release 89: ENSG00000100335 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022412 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Andersson B; Wentland MA; Ricafrente JY; Liu W; Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
"Entrez Gene: SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like".
Dikov, D.; Reichert, A. S. (2011). "How to split up: Lessons from mitochondria". The EMBO Journal. 30 (14): 2751–2753. doi:10.1038/emboj.2011.219. PMC 3160261. PMID 21772324.

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Hartley JL; Temple GF; Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100335 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022412 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid8619474-6] Andersson B; Wentland MA; Ricafrente JY; Liu W; Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[entrez-7] "Entrez Gene: SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like".

[8] Dikov, D.; Reichert, A. S. (2011). "How to split up: Lessons from mitochondria". The EMBO Journal. 30 (14): 2751–2753. doi:10.1038/emboj.2011.219. PMC 3160261. PMID 21772324.

SMCR7L

Function

References

Further reading