SLIT3

Slit homolog 3 protein is a protein that in humans is encoded by the SLIT3 gene.[5][6][7]

SLIT3
Identifiers
Aliases	SLIT3, MEGF5, SLIL2, SLIT1, Slit-3, slit2, slit guidance ligand 3
External IDs	OMIM: 603745 MGI: 1315202 HomoloGene: 2303 GeneCards: SLIT3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q34-q35.1 Start 168,661,733 bp[1] End 169,301,129 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 35,121,224 bp[2] End 35,708,507 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Roundabout binding • calcium ion binding • heparin binding Cellular component • extracellular region • mitochondrion • extracellular Biological process • negative regulation of chemokine-mediated signaling pathway • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration • cell differentiation • negative chemotaxis • Roundabout signaling pathway • negative regulation of gene expression • nervous system development • multicellular organism development • cellular response to hormone stimulus • negative regulation of cell growth • response to cortisol • apoptotic process involved in luteolysis • animal organ morphogenesis • axon extension involved in axon guidance • negative regulation of cell proliferation • axon guidance • aortic valve morphogenesis • atrioventricular valve morphogenesis • ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6586	20564
Ensembl	ENSG00000184347	ENSMUSG00000056427
UniProt	O75094	Q9WVB4
RefSeq (mRNA)	NM_003062 NM_001271946	NM_011412
RefSeq (protein)	NP_001258875 NP_003053	NP_035542
Location (UCSC)	Chr 5: 168.66 – 169.3 Mb	Chr 11: 35.12 – 35.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000184347 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056427 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
6. Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
7. "Entrez Gene: SLIT3 slit homolog 3 (Drosophila)".

Further reading

• Holmes GP, Negus K, Burridge L, Raman S, Algar E, Yamada T, Little MH (December 1998). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis". Mechanisms of Development. 79 (1–2): 57–72. doi:10.1016/S0925-4773(98)00174-9. PMID 10349621.
• Little MH, Wilkinson L, Brown DL, Piper M, Yamada T, Stow JL (August 2001). "Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein". American Journal of Physiology. Cell Physiology. 281 (2): C486-95. doi:10.1152/ajpcell.2001.281.2.c486. PMID 11443047.
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A (January 2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". The Journal of Comparative Neurology. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167.
• Little M, Rumballe B, Georgas K, Yamada T, Teasdale RD (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". The International Journal of Developmental Biology. 46 (4): 385–91. PMID 12141424.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (July 2002). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertension Research. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
• Shi Y, Zhao X, Yu L, Tao R, Tang J, La Y, Duan Y, Gao B, Gu N, Xu Y, Feng G, Zhu S, Liu H, Salter H, He L (July 2004). "Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population". Genome Research. 14 (7): 1345–9. doi:10.1101/gr.1758204. PMC 442150. PMID 15231749.
• Hammond R, Vivancos V, Naeem A, Chilton J, Mambetisaeva E, Mambitisaeva E, Andrews W, Sundaresan V, Guthrie S (October 2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain" (PDF). Development. 132 (20): 4483–95. doi:10.1242/dev.02038. PMID 16162649.
• Lin L, Isacson O (November 2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits". Stem Cells. 24 (11): 2504–13. doi:10.1634/stemcells.2006-0119. PMC 2613222. PMID 16840550.