SLA2

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[5][6]

SLA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M4Z
Identifiers
Aliases	SLA2, C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2
External IDs	OMIM: 606577 MGI: 1925049 HomoloGene: 49989 GeneCards: SLA2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 36,612,318 bp[1] End 36,646,196 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,872,457 bp[2] End 156,887,192 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • protein N-terminus binding • non-membrane spanning protein tyrosine kinase activity • receptor binding • 1-phosphatidylinositol-3-kinase regulator activity Cellular component • cytoplasm • late endosome • cell membrane • endosome membrane • membrane • cytoplasmic vesicle • nucleoplasm • Golgi apparatus • intracellular membrane-bounded organelle • extrinsic component of cytoplasmic side of plasma membrane • phosphatidylinositol 3-kinase complex Biological process • negative regulation of calcium-mediated signaling • negative regulation of B cell activation • intracellular receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • T cell activation • B cell mediated immunity • regulation of immune response • antigen receptor-mediated signaling pathway • positive regulation of signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • cell migration • cell differentiation • peptidyl-tyrosine autophosphorylation • regulation of cell proliferation • innate immune system • regulation of signal transduction • regulation of phosphatidylinositol 3-kinase activity • negative regulation of insulin receptor signaling pathway • phosphatidylinositol phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84174	77799
Ensembl	ENSG00000101082	ENSMUSG00000027636
UniProt	Q9H6Q3	Q8R4L0
RefSeq (mRNA)	NM_032214 NM_175077	NM_029983 NM_001356495
RefSeq (protein)	NP_115590 NP_778252	NP_084259 NP_001343424
Location (UCSC)	Chr 20: 36.61 – 36.65 Mb	Chr 2: 156.87 – 156.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

SLA2 has been shown to interact with Cbl gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101082 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027636 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. CiteSeerX 10.1.1.283.1429. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
6. "Entrez Gene: SLA2 Src-like-adaptor 2".
7. Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

Further reading

• Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v". Oncogene. 22 (2): 266–73. doi:10.1038/sj.onc.1206114. PMID 12527895.
• Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
• Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.