SIAH2

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.[5][6]

SIAH2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSIAH2, hSiah2, siah E3 ubiquitin protein ligase 2
External IDsOMIM: 602213 MGI: 108062 HomoloGene: 21053 GeneCards: SIAH2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q25.1Start150,741,125 bp[1]
End150,763,477 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6478

20439

Ensembl

ENSG00000181788

ENSMUSG00000036432

UniProt

O43255

Q06986

RefSeq (mRNA)

NM_005067

NM_009174

RefSeq (protein)

NP_005058

NP_033200

Location (UCSC)Chr 3: 150.74 – 150.76 MbChr 3: 58.67 – 58.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.[6]

Interactions

SIAH2 has been shown to interact with PEG10,[7] Synaptophysin,[8] PEG3[9] and VAV1.[10]

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References

  1. GRCh38: Ensembl release 89: ENSG00000181788 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036432 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER (October 1997). "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway". Genes & Development. 11 (20): 2701–14. doi:10.1101/gad.11.20.2701. PMC 316613. PMID 9334332.
  6. "Entrez Gene: SIAH2 seven in absentia homolog 2 (Drosophila)".
  7. Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y (June 2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1". Cancer Research. 63 (12): 3043–8. PMID 12810624.
  8. Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L (March 2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". The Journal of Biological Chemistry. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.
  9. Relaix F, Wei XJ, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMC 15761. PMID 10681424.
  10. Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (May 1999). "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Molecular and Cellular Biology. 19 (5): 3798–807. doi:10.1128/mcb.19.5.3798. PMC 84217. PMID 10207103.

Further reading

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